macrolide

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macrolide

 [mak´ro-līd]
1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups.
2. any of a group of antibacterial antibiotics containing such a ring linked to one or more sugars.

mac·ro·lide

(mak'rō-līd),
A natural lactone with a large ring; usually consisting of 14-20 atoms; macrolides include a class of antibiotics discovered in streptomycetes, for example, erythromycin; macrolides also inhibit protein biosynthesis.

macrolide

(măk′rō-līd)
n.
A class of antibiotics that are produced by certain actinomycetes of the genus Streptomyces, are characterized by a large lactone ring linked to one or more sugars, and act by inhibiting protein synthesis.

macrolide

A natural lactone with a large (14–20) carbon ring structure that inhibits protein synthesis; e.g., erythromycin.

mac·ro·lide

(mak'rō-līd)
A natural lactone, with a large ring, usually of 14-20 atoms; several antibiotics, including erythromycin, are macrolides. They inhibit protein biosynthesis.

macrolide

One of a range of antibiotics with a wide spectrum of action that can be used as an alternative to the penicillins to treat respiratory infections including LEGIONNAIRES' DISEASE. The group includes erythromycin, azithromycin and clarithromycin.
References in periodicals archive ?
Tilmicosin is a macrolide antibiotic prepared by chemical alteration of desmycosin and interferes with bacterial protein synthesis (Yazar et al.
In 2001, Japanese scholar Okazaki [10] firstly extracted MP bacterial strain which has drug resistance to macrolide antibiotics from the lower respiratory specimens of children patients with pneumonia and bronchitis.
pneumoniae had already received 14-membered macrolide antibiotics for three days (median) before hospitalization and high fever persisted during hospitalization even with continuing use of macrolides.
Non antimicrobial activity: Apart from its conventional antibacterial action macrolide antibiotics are known to have anti-inflammatory (6), immunomodulator acitivity (7 & 8) and antioxidant properties (9) and Erythromycin has been used clinically for its stimulatory effect on gastrointestinal motility.
The complete structure of the polyene macrolide antibiotic Nystatin A1.
* Vitamin C, macrolide antibiotics, echinacea, ginseng Likely to be ineffective or harmful
Macrolide antibiotics are the first-line treatment for M.
Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics. J Mol Biol.
Macrolide antibiotics have antimicrobial and immunomodulary effects, and chronic administration has been associated with improvements in other Inflamtnatory lung conditions, such as cystic fibrosis.
"Macrolide antibiotics (erythromycin, clarithromycin and azithromycin) are among the most widely prescribed antibiotics, with millions of prescriptions dispensed in Canada each year," said David Juurlink, Scientist at the Sunnybrook Research Institute and the Institute for Clinical Evaluative Sciences.
The well-documented benefits far outweigh the uncertain risks associated with pneumococcal resistance to macrolide antibiotics.
The Company is the largest domestic manufacturer of macrolide antibiotics, with a leading position for its intravenous infusion solution products in high-end hospital market.The Company boasts of its robust brand strength including "Lijunsha", a "Famous Trademark" in China and one of the "Ten Favourite Trademarks" which took over approximately 66% market share in 2008.