macrocycle

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macrocycle

A several-month period of mezocycles of vigourous training followed by short periods of lighter training, as by an athlete preparing for a competitive sports event.
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Tranzyme is also pursuing development of several other macrocyclic compounds emanating from its internal research program, including a second generation, oral ghrelin agonist, TZP-102, currently in Phase 2 trials, and two preclinical compounds, TZP-201 for severe diarrhea indications such as chemotherapy-induced diarrhea, and TZP-301, a ghrelin antagonist, for metabolic disorders.
Patent and Trademark Office (USPTO) for two patent applications entitled "Macrocyclic Modulators of the Ghrelin Receptor" and "Spatially-Defined Macrocyclic Compounds Useful for Drug Discovery".
amp; SHERBROOKE, Quebec -- Tranzyme Pharma, a leading biopharmaceutical company developing novel mechanism-based therapeutics for the treatment of gastrointestinal (GI) and metabolic disorders, announced today the issuance of a European patent (EP 1 218 403) entitled "Combinatorial Synthesis of Libraries of Macrocyclic Compounds Useful in Drug Discovery.