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Ernst, scientist in Hapsburg Empire, 1838-1916. See: Mach band, Mach number.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
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References in periodicals archive ?
Background: Machen graduated from the University of Arkansas with a bachelor's degree in finance.
Essentially, said Machen, examine the bones of your building, determine what needs to get done and develop a capital budget.
(8) The only son in a line of Welsh priests and scholars, Machen and his family faced the hardships of poverty when the great agricultural 'smash' of 1880 wiped out the parish and forced Machen's father to declare bankruptcy.
Machen said, adding that they are both in their late 50s and are more frustrated with the system than are their younger colleagues.
Machen catches regular updates from The Chronicle of Higher Education, the industry journal at
Professor Machen's article demonstrates that he was what modern scholars refer
Machen was a conservative Protestant who opposed prohibition and all other attempts to Christianize the social order.
The new design could boost throughput to 350-400 lb/hr from the present 160-250 lb/hr, Machen says.
Machen lived most of his life in poverty as a clerk, teacher, actor, and translator.
The Great God Pan (1894) was Machen's first novel and the first of many books about black magic and the horrors of the supernatural.
If the rumours are true that there will be no more point-to-point racing at Lower Machen after this year, then it will be a sad day for Welsh hunt-racing.