monoclonal antibodies

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monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The sections were then incubated with the radioiodinated antibodies in the presence of 100 nM concentrations of each of the unmodified mAbs for 1 h at 4[degrees]C.
During the two-part project, MABS relocated and integrated its wheel-and-brake maintenance and repair operations facility from Akron, Ohio, to Danville.
Significantly perhaps, the CD features only two tracks of the duo singing in tandem (well, line and line about, that is); and, indeed, they seldom duetted on the rare occasions that Mabs could be persuaded to appear before a folk revival audience.
The collaboration agreement with Cellectis is a tremendous opportunity for MabQuest to move into clinical development with this new class of anti-PD-1 mAbs. This collaboration will also boost MabQuest's discovery program to develop additional antibody-based strategies to modulate the host immune system, said Dr.
The cross reactivity of mAbs with raw poultry can be readily eliminated by simply heating the samples prior to analysis to avoid false positive results.
The researchers developed a panel of new MAbs that exhibited different reactivity patterns to Campylobacter and C.
However, [T.sub.g] of the PMMA phase of MABS and the PS phase of HIPS is similar and, therefore, the discrimination of MABS and HIPS from ABS1 is very difficult.
Simon Gibson, Mabs Noor, Dennis Roberts and James Norvill join the board, bringing more than 50 years' experience in consultancy and management across the public and private sector to the company.
IF YOU'VE overspent this Christmas, deal with the debt now - that is the stark warning from the Money Advice and Budgeting Service (MABS).
In Granada, an independent government agency--the Municipal Agency Body of Sports (MABS)--funded by city hall runs municipal sports services.
Replication of A/PR/8/34(H1N1) (PR8) virus for >3 weeks in severe combined immunodeficient (SCID) mice that were chronically treated with M2e-specific monoclonal antibodies (MAbs) resulted in the emergence of M2e-escape mutants (28).
Tokyo, Japan, Oct 25, 2005 - (JCNN) - OncoTherapy Science and BioWa jointly announced on October 24 that the two companies have agreed to collaborate in research on cancer-focused monoclonal antibodies (MAbs).