monoclonal antibodies

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monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.

monoclonal antibodies

cloned (i.e. identical) antibodies

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
Although mAbs were originally described in the 1970s, their value has become more widely recognized as scientists have developed more direct and improved approaches to identifying, selecting, optimizing and manufacturing them.
The collaboration agreement with Cellectis is a tremendous opportunity for MabQuest to move into clinical development with this new class of anti-PD-1 mAbs.
The scientists developed the competitive Elisa using each of the two mAbs.
The quality of mAbs depends on the molecular structure, which relies on the reaction conditions, storage and confounding factors in the stability of antibody Increasing the efficiency and biological half-life of antibodies has been a major challenge for scientific centers and trading companies (4) .
Babies whose mothers have a higher score in STAI-S during the first days after birth are evaluated as more "difficult" in MABS scale at 8 weeks.
In-depth analysis of the five mAbs approved for breast cancer, with analysis of their safety, efficacy, treatment patterns and strengths and weaknesses.
MAbs 920, 441, 625 (for the epitopes comprising amino acid residues 135-145, 148-158, and 169-178, respectively) were used as the control antibodies.
Mabs and his business partners turned his idea of an American-style diner mixed with a drinks extravaganza into a reality lastDecember and he's hoping to expand and open other branches around the country soon.
In terms of quality, the Veteran label has excelled even its own exemplary standards with this CD, featuring twenty-eight songs by mother and son combination Mabs and Gordon Hall.
This trend can be attributed to pharmaceutical companies' need to keep their product pipelines full and to several qualities of mAbs that make them particularly attractive to pharma.
Given almost any substance, it is possible to create MAbs that specifically bind to that substance.
success rates were low for compounds that have either been abandoned or approved to date: 8% for all candidates, 10% for small molecule drugs, 9% for monoclonal antibodies (mABs) of all types and 14% for humanized mABs.