monoclonal antibodies

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monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.

monoclonal antibodies

cloned (i.e. identical) antibodies

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
It's easy to mix and match ingredients as you fancy," said Mabs, "and if you have an eye on the waistline you can always use skimmed milk in the very berry milkshake for example and omit the ice-cream.
Mabs and Heather were pouring over the family photograph album (numerous items from which are reproduced in the CD booklet), and when Gordon and I left the room to look at his book collection, Mabs apparently indicated her disdain.
These MAbs were classified into two distinct groups: MAbs specific for C.
Because of the organization's service mission and limited financial resources, the team concluded that the learning and growth and internal process perspectives should be the foundation on which the MABS scorecard is built.
mAbs were purified by protein G column chromatography (Pharmacia Biotech) according to the manufacturer's instructions.
Mabs said the best January sale was at La Senza where the underwear was a bargain.
10, although the family prototypes are recognized by specific MAbs that are not cross-reactive.
Campath (alemtuzumab) is another bioengineered MAB.
He met Supt Tony Melville and Chief Insp Mabs Sohota at the town's police station to discuss improved policing arrangements in the area.
Either ABS or MABS was melt-blended with PA6 at 235[degrees]0 in the compositions of 100/0, 80/20, 60/40, 40/60/, 20/80, and 0/100 wt/wt%.
Production of these smaller units, by bacterial fermentation, should be much cheaper than the cell culture used for MABs, according to Bird, and because the new antibodies have just one chain, they should be less prone than MABs to be knocked off affinity columns during protein separations.