TFAP2A was more strongly correlated with MZF1 ([r.sup.2] = 0.59; P = 1.87 x [10.sup.-7]) and less so with SP1 ([r.sup.2] = 0.46; P = 1.09 x [10.sup.-4]).
Myeloid zinc finger 1 (MZF1, also known as ZNF42) is a two-domain TF, with each domain containing four and nine zinc finger arrangements recognizing separate but similar sequences .
Also, the transcription factor motifs PAX5, EGR1, XBP1, SREBP1, OLF1, MZF1
, NFY, NFKAPPAB, MYCMAX, NFE2, and RP58 may contribute to the pathology of Down syndrome.
Prediction for the binding site of transcription factors with the 5' region of FAS gene Position of Mutation Transcription Transcription the binding site type factor factor Site 1 (-54 bp) T [right arrow] C Oct-1 -- Site 2 (-545 bp) A [right arrow] G -- MZF1
FAS, fatty acid synthase; MZF, myeloid zinc finger protein 1.
They observed that these polymorphisms are predicted to affect Nrf2 ARE-like and MZF1
promoter binding sites .