KAT7

(redirected from MYST2)

KAT7

A gene on chromosome 17q21.32 that encodes a component of the HBO1 complex which is responsible for the bulk of histone H4 acetylation. KAT7 specifically represses AR-mediated transcription; it may regulate DNA replication by chromatin acetylation and act as a coactivator of TP53-dependent transcription.
References in periodicals archive ?
In addition, Oct4 interacts with the transcription factors such as KLF4, SOX2, and TCFCP2L1 and forms complexes with the components of epigenetic machinery such as NuRD, SWI/SNF, PRC1, MYST2, and DNMT3A [70, 71].
In addition, MYST3 was reciprocally upregulated by LPS, while MYST1, MYST2, and MYST5 were only marginally affected.
(2015) The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells.