MYOD1

MYOD1

A gene on chromosome 11p15.4 that regulates myogenesis by encoding MyoD1, a nuclear phosphoprotein with partial homology to the myc family of oncoproteins, which binds to the enhancer sequences of the muscle-specific creatine phosphokinase gene, inhibiting DNA synthesis and cell proliferation. MyoD1 belongs to the basic helix-loop-helix (bHLH) transcription factor family and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenesis, and is involved in muscle regeneration.
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Keratin MnF, desmin, CD34, podoplanin (D2-40), S100, H-caldesmon, myogenin, MyoD1, CD68, p63, human herpes virus 8, and factor XIII are typically negative (Figures 3 through 6).
Thigh meat% and heart% were found to be significantly higher in male Japanese quails treated by FR1 than others showing an aesthetic effect of post-hatch early feeding.This might be due to increased expression of myogenic regulatory factors (MYOD1) in birds with post-hatch immediate access to feed which possibly had enhanced the satellite cells differentiation and led to muscle hypertrophy via myonuclear accretion and protein synthesis as observed by Powell et al.
The tumor did not stain with P16, CEA, beta HCG and P63, desmin, MyoD1, CD10, caldesmon, and cyclinD1.
Markers of muscular differentiation (desmin, myogenin, MyoD1, and smooth-muscle actin) and melanocytic markers (S100-protein, HMB-45, and melan-A) were negative.
Furthermore, LPS was also shown to decrease expression of myogenic factor, including myod1 and myogenin (MyoD1: t = 4.039, P < 0.05 and myogenin: t = 3.300, P < 0.01), but dandelion extract was shown to against this effect of LPS (MyoD1: t = −3.160, P < 0.05 and myogenin: t = −3.207, P < 0.01).
It is important to note that the tumour stained negative for myogenin, myoD1, des-min, S-100, nuclear beta-catenin, and MUC4.
Li, "Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation," Scientific Reports, vol.
Promoter hypermethylation of some other genes like MYOD1, CALCA, hTERT, and RASSF1A can also be detected in serum samples of cervical cancer patients and are related to lymph node metastasis and FIGO stage [42, 43].
NCAM: neural cell adhesion molecule; MAP2: microtubule-associated protein 2; NeuN: neuron-specific nuclear protein; Fit-I: VEGF receptor 1; KDR: VEGF receptor 2; CD34: cluster of differentiation 34; ICAM-I: intercellular cell adhesion molecule-1; vWF: von Willebrand factor, DSP: dentin sialoprotein, DMP1: dentin matrix acidic phosphoprotein 1, BSP: bone sialoprotein, OCN: osteocalcin, MyoD1: myoblast determination protein 1; MHC: major histocompatibility complex; PCR: polymerase chain reaction; FC: flow cytometry; ICC: immunocytochemical.
Other genetic alterations include the NCOA2 gene fusion, which is common in congenital cases, and the MYOD1 gene mutation, which tends to occur in older children and adults.
Hosli et al., "Inv(11)(p13p15) and Myf-3(MyoD1) in a malignant extrarenal rhabdoid tumor of a premature newborn," Pediatric Research, vol.