MYO9B

MYO9B

A gene on chromosome 19p13.1 belonging to the myosin family of actin-based molecular motor heavy chain proteins that binds calmodulin, which serves as a light chain. The MYOB/calmodulin complex displays processive movement on actin filaments toward the minus-end.

Molecular pathology
MYOB polymorphisms are associated with coeliac disease and ulcerative colitis.
References in periodicals archive ?
Wen et al., "Myo9b is a key player in SLIT/ ROBO-mediated lung tumor suppression," The Journal of Clinical Investigation, vol.
The two class IX myosins in mammals, myosin IXa (Myo9a, myr7) and myosin IXb (Myo9b, myr 5), subsist in diverse variations among species (Newman, 2016).
Caption: FIGURE 1: The relationship between different pathophysiological processes implicated in AP and susceptibility genes is concluded as follows: PRSS1: cationic trypsinogen; SPINK1: serine protease inhibitor Kazal type 1; CTRC: chymotrypsin C; ACE: angiotensin- converting enzyme; MIF: migration inhibitory factor; iNOS: inducible nitric oxide synthase; COX-2: cyclooxygenases 2; MYO9B: myosin IXB; TLRs: toll-like receptors; MCP-1: monocyte chemoattractant protein-1; HBDs: human [beta]-defensin 2; MBL2: mannose-binding lectin 2; TNF-[alpha]: tumor necrosis factor-[alpha]; IL-10: interleukin 10; TLR4: toll-like receptor 4.