MYO1G

MYO1G

A gene on chromosome 7p13-p11.2 that encodes a plasma membrane-associated class-I myosin abundant in T cells, B cells and mast cells, which may become immunogenic when it forms a complex with the major histocompatibility complex, and trigger an immune response after recognition by specific T-cells.
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One of the largest EWAS, screening 1062 newborn cord blood samples using Infinium Human Methylation 450 (HM450) platform, has identified hypomethylation of the aryl hydrocarbon receptor repressor (AHRR) and growth factor independent 1 transcription repressor (GFI1) and hypermethylation of cytochrome P450 1A1 (CYP1A1) and myosin IG (MYO1G) that were related to maternal smoking [163].
We found numerous nominally significant novel DMCs at or nearby 450K array-derived, widely replicated smoking-associated locations in or near GFI1, ALPPL2, AHRR, MYO1G, SLC24A3, PPP1R15A (GADD34), and F2RL3 genes (listed in Excel Table S5) and at previously unknown smoking-associated locations in or near HOXA5, RDX, and LRP5.
Four of them, including the most significant one (cg12803068, p = 3.3 x [10.sup.-11]), were located within a 1-kb segment of the myosin IG gene (MYO1G); they were all associated with higher DNAm in exposed than in nonexposed adolescents (Figure 1A and Table 2, model A).
The EWAS-significant CpGs were located in MYO1G and CNTNAP2.
Replication of those 17 sites established an additional 3 gene regions (MYO1G, CNTNAP2, LOC100507468) related to maternal smoking during pregnancy.
Among the 26 CpGs, 8 were within the coding region of growth factor independent 1 transcription repressor (GFI1) on chromosome 1; 4 were within the coding region of aryl-hydrocarbon receptor repressor (AHRR) on chromosome 5; 4 were in a region upstream of cytochrome P450 isoform CYP1A1 on chromosome 15; and 4 were within the coding region of myosin 1G (MYO1G).