MYO18B

MYO18B

A gene on chromosome 22q12.1 that encodes an actin- and ATP-binding motor protein, which is thought to be involved in intracellular trafficking when located in the cytoplasm, and regulation of muscle specific genes once in the nucleus.

Molecular pathology
MYO18B may play a role in controlling tumour development and progression; restoration of MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
References in periodicals archive ?
Uno de los pocos genes, cuya implicacion ha alcanzado significacion estadistica en relacion a las habilidades matematicas, es la variante del gen myosin-18B (MYO18B), que se ha senalado como un buen marcador del rendimiento en esta area (Ludwig et al., 2013).
Etiologies of NB Myopathy NB in other neuromuscular disorders AD: NEB, ACTA1, TPM3, TPM2 Myopathy Idiopathic inflammatory myopathies Acute alcoholic myopathy AR: ACTA1, TPM3, TPM2, TNNT1, Myotonic dystrophy CFL2, KBTBD13, KLHL40, Sarcoglycanopathies KLHL41, LMOD3, MYPN, MYO18B Mitochondrial myopathy GYG1 polyglucosan body myopathy Late-onset Pompe disease Acquired Neuropathy MGUS Spinal muscular atrophy HIV-associated myopathy Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Other Hypothyroidism Chronic renal failure Keys: genes are written in italic font; AD, autosomal dominant; AR, autosomal recessive; NB, nemaline body; MGUS, monoclonal gammopathy of undetermined significance.
To define the molecular network of lung carcinogenesis, systematic analysis of mRNA and protein expression levels of thousands of genes have been accomplished and among them, p53 and RB/p16 defective pathways and expression of several genes such as K-ras, PTEN, FHIT, and MYO18B, have been demonstrated to be altered (109).
Three SNPs on chr17 showed the most significant association and were located in the intergenic regions between Myosin XVIIIB (MYO18B) and seizure related 6 homolog (mouse)-like (SEZ6L).
Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.
MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells.