MYO10

MYO10

A gene on chromosome 19p13.1 that encodes a protein belonging to the myosin family of actin-based molecular motor heavy chain proteins, which binds calmodulin, which serves as a light chain. The MYOB/calmodulin complex displays processive movement on actin filaments toward the minus-end.
 
Molecular pathology
MYOB polymorphisms are associated with coeliac disease and ulcerative colitis.
References in periodicals archive ?
Several genes have been identified as targets of miR-340, including MITF (23), c-Met (12), ROCK1 (36), RhoA (37), Nrf2 (29), p27 (33), MYO10 (34), NRAS (28), MDM2 (35), NF-x03BA, and CTNNB1 (25).
MiR340 suppresses cell migration and invasion by targeting MYO10 in breast cancer.
The molecular motor myosin-X (Myo10) was also proposed as a key regulator of tunneling nanotube formation in murine neuronal (CAD) cells, increasing the occurrence of TNTs and the transfer of vesicles in these TNTs [6].
Furthermore, miR-155 was also demonstrated to inhibit a number of BMP signaling pathways including SMAD1, SMAD5, HIVEP2, CEBPB, RUNX2, and MYO10 [25].
Furthermore, p53 GOF mutants promote the translocation of integrin [beta]1 to the tips of filopodia by increasing the early growth response protein 1- (EGR1-) mediated expression of myosin-X (Myo10), an unconventional myosin [99].