A few studies reported the association of MYH9
or APOL1 with DKD.
The primers utilized in this study are shown as follows: Myh9
F: ACAATGGAGGCCATGAGAAT, Myh9
R: GAGATGACCCGCAGCAAG, Myh10 F: GGAGGACACCCTAGACACCA, and Myh10 R: CCACTTCCTGCTCACGTTTT
Garellek et al., "Glomerular MYH9
expression is reduced by HIV-1," Aids, vol.
Daeihagh et al., "Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an african american homozygous for MYH9
risk variants," Human Pathology, vol.
This variable highly correlated with the ARGs PPIA (0.92), CUL5 (0.51), TSG101 (0.48), IDH1 (0.17), and PECI (0.15), but not GML (-0.16), APOBEC3G (-0.17), MYH9
(-0.17), IL4 (-0.18), TLR9 (-0.18), CXCR1 (-0.25), HLA-C (-0.26), NCOR2 (-0.28), DC-SIGN (-0.29), and TLR8 (-0.36).
Doron Behar of Rambam Medical Center, discovered highly informative DNA markers in the MYH9
Velocardiofacial syndrome, MYH9
gene-related disorders and Jacobsen syndrome (JBS) are well-known inherited syndromes of thrombocytopenias, in which platelets are increased in size and affected probands have unique phenotypic expressions such as cardiovascular, renal, skeletal and gonadal anomalies .
A mutation in the MYH9
gene that encodes for non-muscle myosin heavy chain, a cytoskeletal protein in platelets, may be responsible for the abnormal platelet diameter.
TGF-[beta] and a specific TGF-[beta] inhibitor regulate pericentrin B and MYH9
in glioma cell lines
and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population.
Lu et al., "Differential effects of MYH9
and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans," PLoS Genetics, vol.
Mutations in the MYH9
gene encoding for the nonmuscle myosin heavy chain IIA result in a spectrum of macrothrombocytopenia disorders with neutrophil inclusions referred to as MYH9