MYH8

MYH8

A gene on chromosome 17p13.1 that encodes a heavy chain of myosin and is thus involved in cytokinesis, cell shape and specialised functions—e.g., secretion and capping.

Molecular pathology
MYH8 mutation causes trismus-pseudocamptodactyly syndrome.
References in periodicals archive ?
TGF-[beta] inhibitors (SB431542 or A83-01) significantly facilitated myotube fusion and maturation, as demonstrated by MHC protein levels (MYH1 and MYH8) and sarcomere formation.
The variants identified in DTD1.3ISA were filtered for known pathogenic mutations from the ClinVar database [7,8] in nine genes (TPM2, MYBPC1, MYH3, TNNT3, TNNI2, PIEZO2, ECEL1, MYH8 and FBN2) that had previously been shown to be mutated in persons with DA (OMIM #108120).
Las mutaciones en al menos cinco genes (TNNI2, TNNT3, TPM2, MYH3 y MYH8) que codifican los componentes de las fibras musculares de contraccion rapida puede causar la artrogriposis.
Mutations in at least five genes (TNNI2, TNNT3, TPM2, MYH3 and MYH8) which encode components of the fasttwitch muscle fibers can cause arthrogryposis.
The MYH3 and MYH8 genes are up-regulated in the paretic leg 4.3-fold and 3.7-fold, respectively.