MYH6

MYH6

A gene on chromosome 14q12 that encodes a heavy chain of myosin and is thus involved in cytokinesis, cell shape and specialised functions—e.g., secretion and capping.
 
Molecular pathology
MYH6 mutation causes familial hypertrophic cardiomyopathy and atrial septal defect 3.
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Furthermore, other studies have found that the expression level of myosin heavy chain 6 (MYH6) gene is significantly positively correlated with the density of type I muscle fibers, and sequencing results have indicated that MYH6 gene expression is significantly higher in Mashen pigs compared to Large White pigs.
In fact, transcripts of Myh6, the gene encoding murine a-isoform of myosin heavy chain, are absent in mouse medullary thymic epithelial cells.
also suggested that adipose-derived stem cells (ADSC) on chitosan enhanced the formation of transplantable spheroids with cardiac markers such as Gata4, Nkx2-5, Myh6, and Tnnt2 due to increased calcium signaling [33].
The top 15 hub genes, possessing high degree of connectivity in DCM, are as follows: IL6, MYC, ACTA2, SERPINE1, ASPN, SPP1, KIT, TFRC, FMOD, PDE5A, MYH6, FPR1, C3, CDKN1A, and SOCS3.
Based on independent microarray datasets like GSE3585, GSE3586, and GSE1869, a gene expression signature consisting of 27 genes (e.g., MYH6, MYH10, CCL2, PHLDA1, SNCA, FRZB, SFRP4, SPOCK, CTGF, G0S2, ETV5, and RARRES1) has been identified for DCM, as well as the down-regulation of immune response processes (8).
Did the authors exclude mutations in nDNA-located genes which have been shown to cause dCMP, such as MYH7 , MYBPC3 , LMNA , TNNI3 , TNNT2 , ACTC1 , TPM1 , SCN5A , MYL2 , MYH6 , MYL3 , PLEKHM2 , HAND1 , RBM20 , FBXO32 , DES , YBPC3 , MYPN , and PRKAG2 ?[sup][2] Arguments against the m.8701A>G variant as being causative are that the variant has not been reported as pathogenic, was homoplasmic, that no biochemical defect was demonstrated neither in skeletal muscle nor in skin fibroblasts, that the heteroplasmy rate was not tested in tissues other than lymphocytes, that a maternal trait is not the only possible transmission, that no other organs except the myocardium were affected, and that the variant occurred also in a subject of the control group.
Although iPSC-CMs express relevant ion channel genes (SCN5A, KCNJ2, CACNA1C, KCNQ1, and KCNH2), structural genes (MYH6, MYLPF, MYBPC3, DES, TNNT2, and TNNI3), and transcription factors (NKX2.5, GATA4, and GATA6) [77], they differ from adult ventricular cardiomyocytes in a number of properties.
There are 2 cardiac MHC isoforms, [alpha]- and [beta]-MHC with genes encoding them (MYH6 and MYH7 respectively) located on 14 chromosome.
However, TCDD treatment significantly repressed the expression of Nkx2-5, Shox2, Myh6, Myh7, Cx40, Mlc2v, Hcn4, and Nppa in nonbeating cells and induced Cyp1a1 expression in both beating and nonbeating cells (Figure 2A).
miR-208a and miR-208b are encoded by introns in the MYH6 (myosin, heavy chain 6, cardiac muscle, alpha) and MYH7 genes, respectively.
The results showed that the pluripotency gene POU5F1 (POU class 5 homeobox 1) decreased, while the typical cardiac genes, TNNT2 (troponin T type 2), MYH6 (myosin heavy chain 6), MYL2 (myosin regulatory light chain 2), NKX2.5 (NK2 homeobox 5), and ACTN2 (actinin alpha 2), increased over time (Figure S1).