MXI1

(redirected from MXD2)

MXI1

A gene on chromosome 10q24-q25 that encodes a transcriptional repressor which binds with MAX to form a sequence-specific DNA-binding protein complex.

Molecular pathology
MXI1 mutations are associated with an increased susceptibility to prostate cancer.
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References in periodicals archive ?
Additionally, Flt3-ITD inhibits Foxo3a [16], which in turn suppresses the Myc antagonist Mxi-1 (Mxd2) to increase Myc activity [17].
Conversely, the expression of the Myc antagonists Mxd1 and Mxd2 was increased in a dose-dependent manner in MV4-11 cells treated with PKC412 (Figure 5), as well as the expression of Mxd4, but to a lesser extent.
Our data showed that PKC412-mediated inhibition of FLT3 signaling increased Mxd1 and Mxd2 expression, as well as the expression of Mxd4 and Mnt to a lesser degree, while it reduced cMyc expression in Flt3-ITD AML cells.