MVK


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MVK

A gene on chromosome 12q24 that encodes mevalonate kinase, which plays a regulatory role in cholesterol biosynthesis.

Molecular pathology
Defects in MVK cause mevalonic aciduria and hyperimmunoglobulinaemia D, and periodic fever syndrome.
References in periodicals archive ?
Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome.
A novel MVK splicing mutation, designated as IVS4+1G>A (NM_000431.3), was detected in one patient with facial PK [Figure 1]d.{Figure 1}
Hyperimmunoglobulin D syndrome develops as a result of mutations of the gene coding for the enzyme MVK, which plays a role in cholesterol and isoprenoid synthesis.
This makes MVK a way for people to keep their PINs and passwords safe and in one place.
It also organises two biennial events for the printing and woodworking industries as well as other smaller events.Country: , RussiaSector: Business and Consumer ServicesTarget: International Exhibition Company CJSC (MVK)Buyer: ITE Group plcDeal size in USD: 44mType: Corporate acquisitionFinancing: Debt, Existing resources, CashStatus: Closed
(33) Letter, Jellinghaus to Director of Internal Administration, 15 July 1883, NA, MvK, MR 1883, no.
MVK, which has about five employees, has relocated to leased space within Continental Consolidated's 65,000-square-foot facility at 181 Greenwood St.
Lord Nimmo Smith granted an interim interdict preventing MVK from using the names of the characters, registering them as "domain names" on the internet or offering the web-sites for sale.
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis.
periodic fever syndrome (HIDS)###(MVK)###lymphadenopathy###inhibitors
The hyperimmunoglobulinemia-D and periodic fever syndrome (HIDS) is an autosomal, recessive, inherited, autoinflammatory syndrome characterized by recurrent fever attacks, abdominal pain, lymphadenopathy, skin lesions and joint involvement.[1] The responsible mechanism proposed is a mutation in the gene coding for mevalonate kinase (MVK) which results in a deficiency in the activity of the MVK enzyme enrolling in cholesterol and nonsterol isoprenoid biosynthesis and so called MVK deficiency.[2] Current treatment strategies available for HIDS, however, do not seem to target the underlying pathophysiologic mechanisms of our knowledge.
See National Archive, The Hague (hereafter, NA), Ministerie van Kolonien (Ministry of Colonies) (hereafter, MvK) I, inv.