MPDZ

(redirected from MUPP1)

MPDZ

A gene on chromosome 9p23 that encodes a protein with multiple PDZ domains, which interacts with HTR2C and triggers its clustering at the cell surface. MPDZ is part of the NMDAR signalling complex, which may play a role in controlling AMPAR potentiation and synaptic plasticity in excitatory synapses.
References in periodicals archive ?
GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function.
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. Journal of Biological Chemistry 276(16):12974-12982, 2001.
(2) Detailed expression and sequence analyses subsequently identified a single QTG candidate, Mpdz, which encodes a protein called multi-PDZ domain protein (MPDZ/ MUPP1) (Shirley et al.
[GABA.sub.B] receptor association with the PDZ scaffold Mupp1 alters receptor stability and function.