Based on the structure and function of a molecule, mucin is subdivided into 3 categories: membrane-bound mucins (MUC1, MUC3 MUC4, MUC12, MUC16, MUC17), gel-forming (secreted) mucins (MUC2, MUC5AC, MUC5B, MUC6, MUC19), and soluble mucin (MUC7
Salivary glycoconjugates such as mucins (MUC1, MUC4, MUC5B, MUC7
, and MUC19), proline-rich glycoproteins (PRGs), and kallikrein may also ensure the appropriate hydration of the oral mucosa and maintain the proper pH of the stimulated and nonstimulated saliva [8, 9].
DAMP TLR Refs (i) Biglycan and decorin are degraded TLR2 and by saliva from NOD.B10 mice TLR4  (ii) Versican is increased in SGEC lines TLR2/6  from SS patients heterodimer (i) Fibronectin is dysregulated in salivary  tissue from SS mice and upregulated in  saliva from SS patients  (ii) Calprotectin (S100A8/A9) levels are TLR4  elevated in sera, salivary tissue, and  saliva of pSS patients  (iii) MUC5B and MUC7
are mislocalized  in the ECM of pSS patients  (i) Long interspersed nuclear element 1  (LINE-1) is increased in MSG tissue TLR 7/8  from SS patients
Higher levels of salivary MUC5B and MUC7
in individuals with gastric diseases who harbor Helicobacter pylori .
gene variant produces the protein that makes spit slimy and holds tight to microbes, preventing them from entering your body through your mouth.
5-HTT intron 2 and MUC7
variable number of tandem repeats polymorphisms in a Venezuelan population with asthma or COPD.
Two-hybrid analysis of human salivary mucin MUC7
Relation extraction task was formally put forward in MUC7
by Message Understanding Conference (MUC) supported by Defense Advanced Research Projects committee (DARPA) in 1998.
Over expression, aberrant intracellular localization, and changes in glycosylation of MUC1 and MUC7
are often reported in tumors of colon, breast, ovarian, lung, and pancreatic origin [24, 48].
Human breast tissue was used as a control for MUC1; human colon for MUC2, 3 and 4; human gastric mucosa for MUC5AC and 6; human bronchial mucosa for MUC5B, and human submandibular salivary gland for MUC7
. Negative controls consisted of sections from normal human liver, as it does not express any of these mucin genes.
Sheehan, "Identification of salivary mucin MUC7
binding proteins from Streptococcus gordonii," BMC Microbiology, vol.