Immunohistochemically, both lesions are positive for MUC6
protein (a pyloric gland mucin marker), are negative for MUC5AC (a foveolar mucin marker), and demonstrate a very low proliferative activity index by Ki-67/MIB-1.
pylori provides identification of intestinal metaplasia, which is characterized by reduced expression of gastric mucins (MUC5AC and MUC6
) and de novo expression of MUC2 (20).
El subtipo pancreatobiliar tipicamente muestra expresion CK7 y MUC1, mientras que el subtipo gastrico suele expresar MUC5AC y MUC6
, el intestinal expresa MUC2, CDX2 y CK20, y el oncocitico, MUC1.
In SRCC, accumulation of mucins like MUC1, MUC2, MUC4, MUC5AC, MUC6
results in large vacuoles, which could therefore play a role in carcinogenesis.
No cases of NET Grade 1 and Grade 2 expressed the mucin markers MUC5AC, MUC6
, or MUC2.
Based on the structure and function of a molecule, mucin is subdivided into 3 categories: membrane-bound mucins (MUC1, MUC3 MUC4, MUC12, MUC16, MUC17), gel-forming (secreted) mucins (MUC2, MUC5AC, MUC5B, MUC6
, MUC19), and soluble mucin (MUC7).
Delprado et al., "MUC1, MUC2, MUC4, MUC5AC and MUC6
expression in the progression of prostate cancer," Clinical & Experimental Metastasis, vol.
They are highlighted by a complex growth of small tubular units that diffusely express pyloric gland immunomarker, MUC6
. These showed a more irregular, variegated, and cystically dilated glandular units.
Bcl2, Ccnd1, Cdk6, and Sox4), intestinal stem cells (Lgr5, Olfm4, and Bmi1) , mucin biology (Muc2 and Muc6
), and tight junctions (occludin, zonulin-1, and Jam) was analyzed using real-time PCR (Table S1).
Low numbers of cases and no differential diagnostic value regarding the discrimination of urachal adenocarcinomas from primary bladder and colorectal adenocarcinomas were detected for [alpha]-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), cluster of differentiation 10 (CD10), CK19, Das-1, E48, E-Cadherin, gross cystic disease fluid protein 15 (GCDFP15), mucin 1 (epithelial membrane antigen) (MUC1 (EMA)), mucin 6 (MUC6
), Thrombmodulin, thyroid transcription factor 1 (TTF1), Uroplakin III, Villin, and Vimentin [27, 48, 60, 86, 100, 106, 125, 126, 172, 198, 215, 217, 245, 292, 330].
Immunohistochemically, the glandular cells are focally positive for MUC6
and/or HIK1083 and sometimes diffusely positive for p53.
Concurrently we carried out an immunohistochemical reaction using Muc2, Muc5AC and Muc6