MUC5AC


Also found in: Dictionary.

MUC5AC

A gene on chromosome 11p15.5 that encodes a gel-forming glycoprotein of gastric and respiratory tract epithelia, which protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles, which are subsequently removed by the mucocilary system.

Molecular pathology
MUC5A stains are positive in foveolar dysplasia.
Mentioned in ?
References in periodicals archive ?
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett esophagus ?
Additionally, it was observed that the patients with pancreatic cancer with a positive expression of mRNA MUC5AC had better survival rates than the patients without any mRNA MUC5AC expression [7].
Delprado et al., "MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer," Clinical & Experimental Metastasis, vol.
[24] published an article combining measurements of the standard CA 19-9 assay with detection of CA 199 on proteins mucin MUC5AC and MUC16; the sensitivity of cancer detection was improved relative to CA 19-9 alone in each sample set, achieving 67-80% sensitivity at 98% specificity.
(b) Focal positivity with MUC5AC in pyloric gland adenoma, reiterating mixed-lineage nature of ICPN of the gallbladder.
Kim, "Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions," International Journal of Cancer, vol.
However, cytokeratin (clone: AE1AE3), ^-catenin, progesterone receptor (PgR), thyroid transcription factor- (TTF-) 1, synaptophysin, thyroglobulin, surfactant apoprotein (SPA), epithelial-CMA (EpCAM), MUC5AC (a mucinous-associated protein), neural cell-CAM (NCAM), human melanin black (HMB) 45, and CD20 were negative (Figures 7(a) and 7(b)).
Komiya et al., "Inhibition of IL-13-induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC," Respirology, vol.
Moreover, MUC5AC has been also reported as positive, while hormone receptors, CDX2, MUC1, MUC2, and GCDFP-15, were always unexpressed [3].
As the mucous cell metaplasia developed, it was observed that Muc5ac was the primary airway mucin expressed, which is also characteristic of human asthma [36,37].
In particular, several transmembrane mucins (MUC1, MUC4, and MUC16), and secretion mucins have been identified (MUC2 and MUC5AC) on the ocular surface [6-8].
Tomatidine significantly decreased IL-4, IL-5, IL-13, CCL11, iNOS, MUC5AC, and gob5 gene expression in OVA-sensitized mice and increased the expression of the IFN-[gamma] gene compared to OVA-sensitized mice (Figure 5).