MUC4

MUC4

A gene on chromosome 3q29 that encodes an integral membrane glycoprotein found on cell surfaces, which may play a role in tumour progression by repressing apoptosis. MUC4 may alter cellular behaviour through both its anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as a ligand for ERBB2, the phosphorylation of which plays an important role in epithelial cell proliferation and differentiation.
References in periodicals archive ?
MUC3 and 4 were downregulated (52% in LPR mucosa versus 67% in control mucosa for MUC3 and 69% in LPR mucosa versus 78% in control mucosa for MUC4) whereas MUC1 and 2 were upregulated (21% in LPR mucosa versus 11% in control mucosa for MUC1 and 29% in LPR mucosa versus 11% in control mucosa for MUC2).
En el hombre, los genes que codifican para las mucinas estan programados para configurar 19 familias divididas en dos grupos: el primero son las mucinas ancladas a la membrana, siendo las mas importantes las mucinas MUC1, MUC3, MUC4; el segundo grupo son las mucinas secretadas, siendo las principales las mucinas MUC2, MUC5AC, MUC5B y MUC6.
Description of the FASTUS System Used for MUC4. In Proceedings of the Fourth Message Understanding Conference, 268-275.
Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands.
Experimental studies indicate that tumour overexpression of MUC4 and also CD44 may be further elements that interfere with adequate binding of trastuzumab to its target receptor sites to promote resistance [19].
The research team led by Kermit Carraway have discovered a protein called Muc4, which belongs to a group of proteins called mucins, commonly found in fluids such as tears and mucus.
There are a whole host of trans-membrane mucins, from which I have chosen MUC1 and MUC4 for this presentation.
Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer.
ABSTRACT : In 2004, Jorgensen and coworkers proposed the MUC4 gene as a candidate gene of enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor in piglets and a mutation of G [right arrow] C in intron 7 of MUC4 was identified to be associated with the ETEC F4ab/ac adhesion phenotypes.
One of the promising markers that we are looking at right now is a novel protein called MUC4. One of my colleagues at the University of Nebraska Medical Center, Dr.
In SRCC, accumulation of mucins like MUC1, MUC2, MUC4, MUC5AC, MUC6 results in large vacuoles, which could therefore play a role in carcinogenesis.