* The Company and Sanofi entered into an agreement to restructure their Immuno-oncology Discovery and Development Agreement (Amended IO Discovery Agreement), which narrowed the scope of the existing discovery and development activities conducted by the Company to developing therapeutic bi-specific antibodies targeting BCMA and CD3 (BCMAxCD3) and MUC16
and CD3 (MUC16xCD3).
In our previous study, we reconstructed an associative network for TB and revealed novel candidate genes including CD4, CD69, CD79, CD80, MUC16
, HCST, ADA, CP, SPP1, CXCR4, AGER, and PACRG.
A-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16
is a protein that in humans is encoded by the MUC16
Case Study: An antibody-drug conjugate targeting MUC16
for ovarian cancer.
Quest's Targeted Cancer Therapy Technology includes two potential treatments: AR 9.6, which is an antibody licensed from the University of Nebraska Medical Center that binds to and blocks oncogenic activities of MUC16
as well as ACP-2127, which targets CDK/mTOR receptors.
Based on the structure and function of a molecule, mucin is subdivided into 3 categories: membrane-bound mucins (MUC1, MUC3 MUC4, MUC12, MUC16
, MUC17), gel-forming (secreted) mucins (MUC2, MUC5AC, MUC5B, MUC6, MUC19), and soluble mucin (MUC7).
(3) Lung SCCs are characterized by complex genomic alterations with recurrent mutations in several genes, including TP53, NFE2L2, KEAP1, BAI3, FBXW7, GRM8, MUC16
, RUNX1T1, STK11, ERBB4, DDR2, and FGFR1 amplification.
 published an article combining measurements of the standard CA 19-9 assay with detection of CA 199 on proteins mucin MUC5AC and MUC16
; the sensitivity of cancer detection was improved relative to CA 19-9 alone in each sample set, achieving 67-80% sensitivity at 98% specificity.
In particular, several transmembrane mucins (MUC1, MUC4, and MUC16
), and secretion mucins have been identified (MUC2 and MUC5AC) on the ocular surface [6-8].
analyzed 9 PCNSLs and identified recurrent somatic mutations in 37 genes involved in key biological processes, including transcription ( ETV6, IRF2BP2, EBF1, IRF4, and TBL1XR1 ), cell cycle ( PIM1, BTG1 ), nucleosome assembly ( HIST1H1D, HIST1H2AC ), and cell adhesion ( MUC16
, ACTG1 ), as well as NF-?B and B-cell or T-cell receptor signaling pathways.[sup] Whether PCNSL initially arises inside or outside of the CNS has been a mystery for decades and still confuses us today, the latest discovery from Kazutaka et al.
In total, 8 genes, including MUC16
, UNC79, USH2A, DNAH17, PTPN13, TENM4, PCLO, and PDE1C, were found to be mutated in at least 2 HCC samples (Table 2); 17 candidate somatic mutations located on these genes were further confirmed via PCR-based Sanger sequencing (Figure 2, Table S6).
Ca125 (also known as MUC16
) is a protein that has a well-established role in the PDAC development, especially in the later stages; for instance, it promotes cancer cells motility and drug-resistance and reprograms PDAC metabolism .