MUC13

MUC13

A gene on chromosome 3q21.2 that encodes an epithelial mucin belonging to a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissue, which may play a role in cell signalling.
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The aim of this study was to investigate the insertion/deletion (indel) mutations of the POU domain class 1 transcription factor 1 (POU1F1), the follicle-stimulating hormone b-subunit (FSHb), and themucin 13 (MUC13) genes, as well as to evaluate their associations with testis measurement traits in male piglets.
We found no significant relationships between indels of MUC13 and the testis measurement traits.
Keywords: Pigs; POU1F1 gene; MUC13 gene; FSHb gene; Insertion/deletion (indel).
MUC13 is a transmembranemucin that is highly expressed in the gastrointestinal tract (Williams et al., 2001).
The 68-bp indel mutation in intron 2 of MUC13 has been reported as an important anti-disease genetic marker for molecular breeding in the Yorkshire population(Sun et al., 2015).MUC13 aslo is one of hormonal control of mucin proteins (Poonet al., 2014).
Related studies have identified a number of different indels in POU1F1, FSHb, and MUC13. The purpose of this study was to investigate the indels of POU1F1, FSHb, and MUC13 in the Large White (LW) and Landrace (LD) pigs, two of the most popular breeds in many countries, including China (Bergfelder-Druing et al., 2015), and to evaluate their association with testis measurement traits in male piglets for the first time.
Primer design and PCR amplification: Three pairs of PCR primers for POU1F1,FSHb, and MUC13 were designed according to Song et al.
The frequency of the indel variants: In this study, the indel variants of POU1F1, FSHb, and MUC13 were investigated using polyacrylamide gel electrophoresis analysis.
MUC13 also showed three genotypes: AA (151 bp), BB (83 bp), and AB (151 bp, 83 bp) (Fig.1c).
Furthermore,the B allelic frequencies in LD and LW breeds, respectively, were 0.902 and 0.664 for FSHb and 0.825 and 0.580 for MUC13. In order to evaluate genetic diversity, we calculated homozygosity (Ho), heterozygosity (He), effective allele numbers (Ne), and PIC at each locus (Table 2).
Indeed, binding of IL-22 to its heterodimeric receptor, comprising IL10R2 and IL-22R1, on epithelial cells triggers the transcription factor STAT3, thereby promoting synthesis of antimicrobial peptides and proteins (i.e., [beta]-defensins, RegIII[beta] and RegIII[gamma], calgranulins S100A8 and S100A9, and lipocalin-2) and elevated levels of mucus-associated molecules (i.e., Muc1, Muc3, Muc10, and Muc13), with the downstream effect of limiting the translocation of commensal bacteria across the epithelial barrier during inflammation [47].
Goblet cells produce secretory (MUC2, MUC5AC, MUC5B, and MUC6), membrane-associated mucins (MUC1, MUC3, MUC4, MUC13, and/or MUC17), and trefoil factors (TFF1-3), which are responsible for epithelial restitution [2, 7].