MUC1


Also found in: Acronyms.

MUC1

A 265- to 400-kD transmembrane glycoprotein encoded by MUC1 on chromosome 1q21, which is found in milk-fat globule membranes.

Normal expression
Normal epithelia and perineurial cells, choroid plexus, arachnoid granulation, epithelioid histiocytes.

Abnormal expression
Neoplastic epithelia, meningiomas, mesotheliomas, mesenchymal tumours, some lymphomas, anaplastic large cell lymphomas.
References in periodicals archive ?
Gold [11] described a positive reaction of MUC1 in 87% of pancreatic ductal adenocarcinoma cases, though, similarly to our study, he observed no positive expression of this protein in normal pancreatic ducts.
Mizutani, "Expression of MUC1 and MUC2 in ampullary cancer," International Journal of Surgical Pathology, vol.
Finn, "MUC1 protein expression in tumor cells regulates transcription of proinflammatory cytokines by forming a complex with nuclear factor-xB p65 and binding to cytokine promoters: Importance of extracellular domain," The Journal of Biological Chemistry, vol.
Other similar studies of CAR T-cells targeting MUC1 [64], CD24 [65], and HER2 [65] were tested, leading to tumor regression in mice.
MUC1 is a membrane-bound mucin with a high expression throughout the distal nephron and is involved in the protection and lubrication of the distal tubular lumen [12,13].
Moreover, MUC5AC has been also reported as positive, while hormone receptors, CDX2, MUC1, MUC2, and GCDFP-15, were always unexpressed [3].
Mucin 1 (MUC1) is a transmembrane glycoprotein functioning as an adhesion molecule which, in its circulating form, is identified as the serum tumor marker CA 15-3.
Immunohistochemically, our tumor was positive for vimentin, CD34, and renin, along with CD10, MUC1, smooth muscle actin, and caldesmon, while it was negative for cytokeratin (AE1/AE3), EMA, CD99, HMB45, and STAT6.
In particular, several transmembrane mucins (MUC1, MUC4, and MUC16), and secretion mucins have been identified (MUC2 and MUC5AC) on the ocular surface [6-8].
However, sometimes they can show focal staining with MUC5A (a foveolar marker, positive in gastric foveolar-type adenomas, Figure 2(b)) and MUC1 (a pancreatobiliary marker, positive in biliary-type adenomas).
A specific type of single cytosine insertion in the variable number tandem repeat (VNTR) of the mucin 1 (MUC1) gene is the only known cause of MCKD1; however, genetic analysis of this mutation is difficult and not yet offered routinely.