MUC5AC

(redirected from MUC-5AC)

MUC5AC

A gene on chromosome 11p15.5 that encodes a gel-forming glycoprotein of gastric and respiratory tract epithelia, which protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles, which are subsequently removed by the mucocilary system.

Molecular pathology
MUC5A stains are positive in foveolar dysplasia.
Mentioned in ?
References in periodicals archive ?
Staining with MUC-1 and MUC-5AC is most likely to be definitive.
We thus interrogated a nasolabial cyst tissue biopsy from a 36-year-old woman patient cared for at our institution with a panel of monoclonal antibodies against various cytokeratins (CKs; CK5/6, CK7, CK19, CK20, and high molecular weight cytokeratins [monoclonal antibody clone 34[beta]E12]), p63, and the mucin proteins MUC-2 and MUC-5AC (Figure 5, A through D).
Using antibodies against 2 secreted mucin proteins, we discovered that some luminal goblet cells expressed MUC-2 (weakly), whereas virtually all goblet cells strongly expressed MUC-5AC (Figure 5, C and D).
Haab's) identification of variants of MUC-1, MUC-5AC, and MUC-16 (genes) within the cyst fluid of pre-malignant lesions is exciting as our current ability to non-operatively define these lesions is limited.