NUDT1

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NUDT1

A gene on chromosome 7p22 that encodes an antimutagenic enzyme which prevents misincorporation of 8-oxo-dGTP into DNA, thus blocking A:T to C:G transversions.
References in periodicals archive ?
MTH1, NUDT15 and OGG1, and use our newly developed inhibitors to increase our knowledge of these enzymes in oxidative metabolism and disease.
According to the contract, both firms will share intellectual property and jointly fund ten research projects, resulting in the design of multiple new inhibitors of the MTH1 protein, an enzyme required for cancer cell proliferation.
Moreover, urinary 8-oxodGuo may also originate from the hydrolysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) in the nucleotide pool by the 8-oxodGTPase enzyme, the so-called MTH1 protein (5,6).
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins.