MMP17

(redirected from MT4-MMP)

MMP17

A gene on chromosome 12q24.3 that encodes membrane-type matrix metalloproteinase 17. Unlike other matrix metalloproteinaes, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP17 is membrane bound as a GPI-anchored protein. It activates MMP2 by cleavage; it does not hydrolyse collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin or alpha1-antitrypsin.

References in periodicals archive ?

Besides MMP-2 and MMP-3, putative NLSs in the sequences of MMP-1, MMP-8, MMP-10, MMP-13, MMP-19, MMP20, and MMP-23 and MT1-MMP, MT3-MMP, MT4-MMP, and MT5-MMP were also detected [31], which suggests that nuclear entry may be a feature of many MMPs.

Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

MT4-MMP has an unknown mechanism of involvement in breast carcinoma, being also expressed in breast cancer cell lines.

Metalloproteinases involvement in liver tumoral pathology-an update

Membrane-type (MT)-MMPs consist of four transmembrane MMPs, MMP-14 (MT1-MMP), MMP-15 (MT2-MMP), MMP-16 (MT3-MMP), and MMP-24 (MT5MMP) and two glycosyl-phosphatidylinositol-anchored MMPs, MMP-17 (MT4-MMP) and MMP-25 (MT6-MMP).

Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling

Grupo Colagenases MMP Nome enzimatico MMP-1 Colagenase intersticial MMP-8 Neutrofilo colagenase MMP-13 Colagenase-3 Gelatinases MMP-2 Gelatinase A MMP-9 Gelatinase B Estromalisinas MMP-3 Estromalisina-1 MMP-10 Estromalisina-2 MMP-11 Estromalisina-3 MMPs tipo MMP-14 MT1-MMP membrana MMP-16 MT3-MMP MMP-17 MT4-MMP MMP-24 MT5-MMP MMP-25 MT6-MMP Outras MMP-7 Matrilisina MMP-26 Matrilisina-2 MMP-12 Macrofago metaloelastase

Matrix metalloproteinases in corneal repair. Review/Matriz metaloproteinases na reparacao corneal. Revisao de literatura/Metaloproteinasas de matriz en la reparacion de la cornea. Revision de literatura

Membrane-anchored MMPs include MT1-MMP (MMP14), MT2-MMP (MMP15), MT3-MMP (MMP16), MT4-MMP (MMP17), MT5-MMP (MMP24), MT6-MMP (MMP25), and MMP23.

Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis