MT1MMP | definition of MT1MMP by Medical dictionary
MMP14 (redirected from MT1MMP)
MMP14 A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
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References in periodicals archive
Variables Values [a.sub.0] 2.0 x [10.sup.6] [M] [b.sub.0] 1.0 x [10.sup.6] [M] [c.sub.0] 1.0 x [10.sup.6] [M] [k.sub.1] 2.1 x [10.sup.7] [M.sup.-1][s.sup.-1] [l.sub.1] 0 [M.sup.-1][s.sup.-1] [k.sub.2] 2.74 x [10.sup.6] [M.sup.-1][s.sup.-1] [l.sub.2] 2.0 x [10.sup.-4] [M.sup.-1][s.sup.-1] [k.sub.3] 2.0 x [10.sup.6] [M.sup.-1][s.sup.-1] [l.sub.3] 1.0 x [10.sup.-2] [M.sup.-1][s.sup.-1] FIGURE 2: Binding sites of a (MMP2), b (TIMP2), and c (MT1MMP
Rapti et al., "The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1MMP
) in a cell-based environment," Cancer Letters, vol.
The variable ability of tumor cell lines to bind progelatinase A with or without enzyme activation suggests the presence of a progelatinase A receptor distinct from MT1MMP
receptor, such as integrin [alpha]v[beta]3 of the surface of cultured melanoma cells .
Therefore, we examined whether VPA stimulates the expression of MMP-2 and MT1MMP
in CB MSC.
Estrogen deficiency induced by ovariectomy gives rise to a reduction of active MMP-2 in the initial phase and a concurrent elevation of MMP-2 and MT1MMP expression in latter period .
Bone marrow-derived stem cells (BMSCs) induce an angiogenic effect and elicit vessel morphogenesis both in vitro and in vivo depending on proteolytic ability of MT1MMP .