MMP14

(redirected from MT1-MMP)

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
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It was reported that the activation of MMP-2 in cervical cancer tissue could be mediated by a functional complex consisting of [alpha](v)[beta]3 integrin/membrane type-1 metalloproteinase-2 (MT1-MMP)/tissue inhibitor of metalloproteinase-2 (TIMP-2) on tumor cell surface (24).
Fetal insulin and IGF-II contribute to gestational diabetes mellitus (GDM)-associated up-regulation of membrane-type matrix metalloproteinase 1 (MT1-MMP) in the human feto-placental endothelium.
Galvez, "Matrixmetalloproteinases:New routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease," Current PharmaceuticalDesign, vol.
Thompson, "High threshold of integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)," Cancer Cell International, vol.
Depending on the substrate specificity and structure, MMPs are divided into several subgroups: collagenases (e.g., MMP-1), gelatinases (e.g., MMP-2 and MMP-9), stromelysins (e.g., MMP-3 and MMP-10), matrilysins (e.g., MMP-7 and MMP-26), and membrane-type matrix metalloproteinase-1 (MT1-MMP).
[16], who developed a radiolabelled peptide probe by adding a Cys residue at the N-terminus of the peptide MT1-AF7p to allow facile radiolabelling of the thiol moiety by N-(m-[[sup.123/125]I]iodophenyl) maleimide ([123/125I]IPM) for SPECT/CT imaging in HT1080-tumour-bearing mice (HT1080 is a human fibrosarcoma cell line known to highly express MT1-MMP); the radiolabelled probe was therefore similar to DOTA-AF7p but with IPM instead of DOTA.
Galvez, "Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease," Current Pharmaceutical Design, vol.
MT1-MMP has been shown to enhance the basic fibroblast growth factor- (bFGF-) induced CNV in vivo [11].
Characterization of the distinct collagen binding and cleveage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the different roles of the MMP hemopexin C domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities.
The vascular reactivity and time-course changes of collagen type I, MMP-2, membrane type 1-MMP (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) protein expression in mesenteric arteries were evaluated.
Tissue sections (7 pm) from middermal elastolysis or healthy control skins were used for immunohistochemical analysis of MMP-3, MMP9, MMP-2, MMP-1, TIMP-2, and MT1-MMP (MMP-14).