It was reported that the activation of MMP-2 in cervical cancer tissue could be mediated by a functional complex consisting of [alpha](v)[beta]3 integrin/membrane type-1 metalloproteinase-2 (MT1-MMP
)/tissue inhibitor of metalloproteinase-2 (TIMP-2) on tumor cell surface (24).
Fetal insulin and IGF-II contribute to gestational diabetes mellitus (GDM)-associated up-regulation of membrane-type matrix metalloproteinase 1 (MT1-MMP
) in the human feto-placental endothelium.
Membrane-type 1 matrix metalloprotease (MT1-MMP
) enables invasive migration of glioma cells in central nervous system white matter.
Galvez, "Matrixmetalloproteinases:New routes to the use of MT1-MMP
as a therapeutic target in angiogenesis-related disease," Current PharmaceuticalDesign, vol.
Thompson, "High threshold of integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP
) activation of matrix metalloproteinase 2 (MMP-2)," Cancer Cell International, vol.
Depending on the substrate specificity and structure, MMPs are divided into several subgroups: collagenases (e.g., MMP-1), gelatinases (e.g., MMP-2 and MMP-9), stromelysins (e.g., MMP-3 and MMP-10), matrilysins (e.g., MMP-7 and MMP-26), and membrane-type matrix metalloproteinase-1 (MT1-MMP
, who developed a radiolabelled peptide probe by adding a Cys residue at the N-terminus of the peptide MT1-AF7p to allow facile radiolabelling of the thiol moiety by N-(m-[[sup.123/125]I]iodophenyl) maleimide ([123/125I]IPM) for SPECT/CT imaging in HT1080-tumour-bearing mice (HT1080 is a human fibrosarcoma cell line known to highly express MT1-MMP
); the radiolabelled probe was therefore similar to DOTA-AF7p but with IPM instead of DOTA.
Galvez, "Matrix metalloproteinases: new routes to the use of MT1-MMP
as a therapeutic target in angiogenesis-related disease," Current Pharmaceutical Design, vol.
has been shown to enhance the basic fibroblast growth factor- (bFGF-) induced CNV in vivo .
Characterization of the distinct collagen binding and cleveage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP
): the different roles of the MMP hemopexin C domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities.
The vascular reactivity and time-course changes of collagen type I, MMP-2, membrane type 1-MMP (MT1-MMP
), and tissue inhibitor of metalloproteinase-2 (TIMP-2) protein expression in mesenteric arteries were evaluated.
Tissue sections (7 pm) from middermal elastolysis or healthy control skins were used for immunohistochemical analysis of MMP-3, MMP9, MMP-2, MMP-1, TIMP-2, and MT1-MMP