STK24

(redirected from MST3B)

STK24

A gene on chromosome 13q31.2-q32.3 that encodes a serine/threonine-protein kinase which acts on serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. STK24 mediates oxidative-stress-induced cell death by phosphorylating JNK1-JNK2 (MAPK8 and MAPK9) and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. It regulates cellular migration by altering PTPN12 activity and PXN phosphorylation, and it may be a key regulator of axon regeneration in the optic and radial nerves.
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For example, inosine triggers a serine/threonine kinase (Mst3b), enhancing axonal sprouting [13, 14].
Irwin, "Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways," Nature Neuroscience, vol.
Washington, Oct 26 (ANI): A previously identified enzyme, known as Mst3b, has been found to play a major role in regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral and central nervous systems, according to researchers at Children's Hospital Boston.
The findings indicate that Mst3b - or agents that stimulate it - could be a possible means of treating stroke, spinal cord damage and traumatic brain injury.
Mst3b, a protein kinase, in turn activates signals that switch on the genes necessary for axons to grow.
Working with live rats whose optic nerve was damaged (a common model of central-nervous-system injury), the researchers showed that in the absence of Mst3b, axons show very little regeneration, even in the presence of factors known to enhance axon growth.
In cell cultures, axon growth increased when activated Mst3b was expressed in the neurons.
"All the growth factors we've tested - oncomodulin, inosine, brain-derived neurotropic factor, nerve growth factor - act through Mst3b. In fact, activating Mst3b by itself is enough to cause growth even if there are no growth factors around.