Although MST1 and MST2 have been shown to have the same effects in many studies [4, 27-29], they may not be equivalent in SAH.
Kong et al., "Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration," Science Translational Medicine, vol.
Based on the evidence that MST2
knockout mice showed attenuated hypertrophy while MST2
overexpression lead to increased hypertrophy, researchers concluded that MST2
took part in cardiac hypertrophy .
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2
inhibits cell proliferation.
Mst1 and Mst2
kinases regulate the activation of RhoA and the migratory responses of SP thymocytes [111, 112].
The RAF-1 kinase also inhibits cell death pathways mediated by apoptosis signal-regulating kinase 1 (ASK1) as well as mammalian sterile 20 kinase 2 (MST2
RAF1 is able to block two proapoptotic kinases, ASK1 and MST2
, important in ROS-induced damage .
The MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, consists of five related proteins: STK3 (also known as MST2
), STK4 (also known as MST1), STK24 (also known as MST3), STK25 (also known as YSK1), and STK26 (also known as MST4) .
The mammalian Hippo pathway includes STE20 family protein (MST) kinases (MST1 and MST2
) and large tumor suppressor (LATS) kinases (LATS1 and LATS2) .
(3) Sequence boundary Tc 2: According to Duarte (1997a; 1997b - herein designated as DT2) this sequence boundary marks the boundary between tenuicostatum and serpentinum Zone and between MST1 and MST2
. At some localities within the Lusitanian Basin it forms an erosional surface.
Its targets are MST2
, CDC42, and RHOA, which results in activation of AKT and ERK signalling pathways .
It is noteworthy that although [Mst.sup.1-/-] or [Mst2.sup.-/-] mice developed normally, homozygous disruption of both Mst1 and Mst2
led to increased apoptosis in embryos, a secondary response to placental functional defects in these mice .