STK3

(redirected from MST2)

STK3

A gene on chromosome 8q22.2 that encodes a stress-activated, pro-apoptotic kinase which, following caspase cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK3 and STK4 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis. STK3 is also a less preferred gene symbol for what is now designated as STK24, see there.
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Although MST1 and MST2 have been shown to have the same effects in many studies [4, 27-29], they may not be equivalent in SAH.
Kong et al., "Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration," Science Translational Medicine, vol.
Based on the evidence that MST2 knockout mice showed attenuated hypertrophy while MST2 overexpression lead to increased hypertrophy, researchers concluded that MST2 took part in cardiac hypertrophy [20].
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
Mst1 and Mst2 kinases regulate the activation of RhoA and the migratory responses of SP thymocytes [111, 112].
The RAF-1 kinase also inhibits cell death pathways mediated by apoptosis signal-regulating kinase 1 (ASK1) as well as mammalian sterile 20 kinase 2 (MST2).
RAF1 is able to block two proapoptotic kinases, ASK1 and MST2, important in ROS-induced damage [32].
The MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, consists of five related proteins: STK3 (also known as MST2), STK4 (also known as MST1), STK24 (also known as MST3), STK25 (also known as YSK1), and STK26 (also known as MST4) [19].
The mammalian Hippo pathway includes STE20 family protein (MST) kinases (MST1 and MST2) and large tumor suppressor (LATS) kinases (LATS1 and LATS2) [12].
(3) Sequence boundary Tc 2: According to Duarte (1997a; 1997b - herein designated as DT2) this sequence boundary marks the boundary between tenuicostatum and serpentinum Zone and between MST1 and MST2. At some localities within the Lusitanian Basin it forms an erosional surface.
Its targets are MST2, CDC42, and RHOA, which results in activation of AKT and ERK signalling pathways [21].
It is noteworthy that although [Mst.sup.1-/-] or [Mst2.sup.-/-] mice developed normally, homozygous disruption of both Mst1 and Mst2 led to increased apoptosis in embryos, a secondary response to placental functional defects in these mice [182].