STK4

(redirected from MST1)

STK4

A gene on chromosome 20q11.2-q13.2 that encodes a ubiquitously expressed, stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK4 and STK3 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis.
Mentioned in ?
References in periodicals archive ?
MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1. Biochem J 2013; 452: 281-291, doi: 10.1042/BJ20120680.
On the other hand, an exquisite study showed that mammalian sterile 20-like kinase 1 (MST1) signaling from DCs negatively regulated Th17 differentiation.
found that MST1 suppression could reduce early brain injury after subarachnoid hemorrhage in mice.
This proposal has been reinforced with the new discovery of genetic associations with each respective phenotype, including genetic loci of 2p15(REL), 3p21(MST1), and 9q35(CARD9) [23].
With the method of high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation (HITS-CLIP), the miR302-307 target genes Mst1, Lats2, and Mob1b are found to be components of Hippo signaling pathway, indicating the effect of miR302-367 on CM proliferation might be through repression of the Hippo signal transduction pathway [24].
Lehtinen and colleagues elegantly demonstrated the activation of Mst1, a serine/threonine kinase activated in the Hippo cascade, upon oxidative stress induced by exposure to increasing concentrations of exogenous [H.sub.2][O.sub.2].
elegans homolog of the mammalian Ste20-like kinase MST1, regulates daf-16 in response to oxidative stress [40].
Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.
Chernoff, "The tumor suppressor MST1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein," The Journal of Biological Chemistry, vol.
RASSF1A promotes and maintains phosphorylation of MST1, and also activates Bax leading to the induction/activation of down stream of proapoptotic genes such as puma and caspases 3 and 7 genes [13-17].
For example, AKT interacts with MST1, a hippo-like serine-threonine kinase [96].