STK4

(redirected from MST1)

STK4

A gene on chromosome 20q11.2-q13.2 that encodes a ubiquitously expressed, stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK4 and STK3 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis.
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FOXO1 is phosphorylated using different kinases, all kinases except cyclin dependent kinase 1 (CDK1) and MST1 reduces the DNA binding affinity and nuclear localization (Yuan et al.
58 MST1 macrophage stimulating 1 (hepatocyte growth factor-like) Hs.
2) Depositional sequence Tc 1: Duarte (1997a; 1997b) determined this sequence as MST1 (MS for mesosequence, T for Toarcian) which, in his opinion, spans the hole tenuicostatum Zone as an independent megasequence (ME1).
3) Sequence boundary Tc 2: According to Duarte (1997a; 1997b - herein designated as DT2) this sequence boundary marks the boundary between tenuicostatum and serpentinum Zone and between MST1 and MST2.
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.