STK4

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STK4

A gene on chromosome 20q11.2-q13.2 that encodes a ubiquitously expressed, stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK4 and STK3 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis.
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References in periodicals archive ?
The successful test of the Motor Structural Test (MST-1) case represents a significant milestone on the path to qualifying the abort motor production design.
During the MST-1 qualification test, the case withstood axial tension and compression loads in excess of a half-million pounds, as well as simultaneous side loads.
MST-1 is one in a series of full scale structural qualification tests.