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Related to MSR1: Macrophage Scavenger Receptor 1
MSR1A gene on chromosome 8p22 that encodes the class-A macrophage scavenger receptors, which include three different types (1, 2 and 3) generated by alternative splicing of MSR1. The receptor isoforms have been implicated in both macrophage-associated physiological and pathological processes, including atherosclerosis, Alzheimer's disease and host defence.
Defects in MSR1 have been linked to an increased susceptibility to prostate cancer and Barrett’s oesophagus.