RPS6KA4

(redirected from MSK2)

RPS6KA4

A gene on chromosome 11q11-q13 that encodes a p90 ribosomal S6  serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factor RELA. RPS6KA4 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it is thought to induce transcription of the MAP kinase phosphatase DUSP1 and IL10 (an anti-inflammatory cytokine) via CREB1 and ATF1 transcription factors.

Molecular pathology
Aberrant activation of p90 RSKs has been linked to breast and prostate cancers.
References in periodicals archive ?
miR-93 has an important role in chromatin reorganization by modulating its target MSK2, a histone kinase, and its substrate H3S10, and miR-93 constitutive expression is required to maintain podocyte health.
Arthur, "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts," Molecular and Cellular Biology, vol.
For the kinases MSK1 and MSK2 that are phosphorylated by p38 MAPK and Erk and exert many negative feedback mechanisms in TLR signaling including IL-10 gene upregulation, LTA and CpG DNA as well as LPS have been shown to trigger activation of their kinase activities [34] For CD200, a cellsurface glycoprotein whose binding to CD200R triggers diverse immune inhibitory mechanisms, a range of TLR agonists such as LPS, PGN, poly (I:C), and CpG DNA can induce CD200 mRNA in macrophages in a c-Rel-dependent manner [35].
Naqvi et al., "MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop," Molecular and Cellular Biology, vol.
This response is mediated by the mitogen- and stress-activated kinases 1 and 2 (MSK1 and MSK2), which are, in turn, activated by p38 MAP kinase (MAPK) [55, 56].