ITGB1

(redirected from MSK12)

ITGB1

A gene on chromosome 10p11.2 that encodes an integrin beta chain protein, which forms part of receptors (with different alpha chains) for collagen, fibronectin, fibrinogen, laminin, VCAM1, cytotactin, osteopontin, vitronectin, epiligrin, thrombospondin and CSPG4. It is involved in embryogenesis, haemostasis, tissue repair, immune response and metastatic spread of malignant cells.
References in periodicals archive ?
It has an essential role in differentiation of neural stems cells and neural progenitor cells (34), and its downregulation promotes growth, invasiveness, and metastasis (35) by targeting laminin, gamma 1 (LAMC1), integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), cyclin-dependent kinase 6 (CDK6), and SRY (sex determining region Y)-box9 (SOX9) (36).