ABCC5

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ABCC5

A gene on chromosome 3q27 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC5 exports its substrate, cyclic nucleotides, contributing to the degradation of phosphodiesterases, and may be an elimination pathway for cyclic nucleotides. ABCC5 is linked to resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, in patients with acute lymphocytic leukaemia, and resistance to antiretroviral nucleoside analogues (e.g., 9-(2-phosphonylmethoxyethyl)adenine) in HIV-infected patients.
References in periodicals archive ?
Kroemer, "Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)," Drug Metabolism Reviews, vol.
Hatse et al., "Role of MRP4 and MRP5 in biology and chemotherapy," AAPS PharmSci, vol.
Expression of drug resistance proteins Pg[micro]MRP1, MRP3, MRP5 and GST-pi in human glioma.
MRPs have been reported to confer resistance to various anticancer drugs and, in gliomas, MRP1, MRP3, MRP4, and MRP5 have been reported to be expressed more than the other members [19, 20].
In a previous study we investigated the MRP5 expression which can be normally found in the astrocytes of the subcortical white matter and in the pyramidal neurons [10].
Heijn et al., "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, MDR3 P-glycoprotein with a panel of monoclonal antibodies," Cancer Research, vol.
However, controlled price at milling (MRP3) and different pricing mechanism (MRP5), both were loaded on fifth actor; have been removed from this factor.
Although the differentiation-dependent and sterol-regulated induction of ABCA1 and ABCG1 is well established (7), parallel transcript profiling, using our Human ABC Transporter TaqMan Low-Density Array, revealed several additional differentiation-dependent ABC transporters and novel LXR/RXR-regulated ABC transporters, including ABCB1 (MDR1), ABCB9, ABCB11 (BSEP), ABCC2 (MRP2), ABCC5 (MRP5), ABCD1 (ALD), ABCD4, and ABCG2.
Heijn et al., "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies," Cancer Research, vol.
TTS also repressed expression of many other MDR genes, such as MRP1, MRP2, MRP3, MRP5, MVP and GST-[pi].
Pericytes express MRP1, MRP4, and MRP5 transporters, which might imply a role played by these cells in regulating xenobiotic transport through the BBB [74].
MRP2, MRP4 and MRP5 are expressed in all cell variants, but the expression levels are differently distributed.