ABCC4

(redirected from MRP4)
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ABCC4

A gene on chromosome 13q32 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC4 is thought to play a role in cellular detoxification as an organic anion pump.

References in periodicals archive ?

Kroemer, "Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)," Drug Metabolism Reviews, vol.

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Zelcer et al., "The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs," Proceedings of the National Academy of Sciences of the United States of America, vol.

ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population

Nakamura et al., "The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene," The Journal of Pharmacology and Experimental Therapeutics, vol.

A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics

In these cells, n-3 PUFAs reduce transcript levels of the BA synthesizing enzymes CYP7A1, CYP27, and CYP8B1 and of the apical BA importer NTCP, while increasing those of the BA exporters MRP2, MRP3, MRP4, and OST[beta] and of the metabolizing SULT2A1 enzyme (Figure 6).

N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models

Guibert et al., "Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice," The Journal of Clinical Investigation, vol.

Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after [PM.sub.2.5], Budesonide, and Cotreated Exposures

Temperilli et al., "Enhanced platelet MRP4 expression and correlation with platelet function in patients under chronic aspirin treatment," Thrombosis and Haemostasis, vol.

Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance

Genes of interest were analyzed using TaqMan Master Mix and TaqMan Gene Expression Assays (Life Technologies): Sodium-dependent glucose cotransporter 1 (Sglt1), Rn00564718_m1; Sglt2, Rn00574917_m1; Oat1, Rn00568143_m1; Oat2, Rn00585513_m1; Oat3, Rn00580082_m1; Oct1, Rn00562250_m1; Oct2, Rn00580893_m1; Mrp2, Rn00563231_m1; Mrp4, Rn01465702_m1; P-glycoprotein (Mdr1b), Rn00561753_m1; Hnf1[alpha], Rn00562020_m1; Hnf1[beta], Rn00447453_m1; Hnf4[alpha], Rn00573309_m1.

Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats

Cells were treated with 25 p.M DAS, DADS and DAIS for 24 and 48 h and gene expression levels in colo 205 cells were determined for MRP1, MRP3, MRP4 and MRP6.

Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo

UDCA treatment of WT mice significantly increased nuclear Nrf2 expression and that of hepatic Mrp2, Mrp3, and Mrp4 [127].

Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury

For example, knocking out the gene encoding for MRP4 increases inflammatory pain threshold [45] and knocking out the gene encoding for MRP3 alters morphine pharmacokinetics [44].

Neurovascular unit in chronic pain

MRP2, MRP4 and MRP5 are expressed in all cell variants, but the expression levels are differently distributed.

Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells

In particular, aspirin, indomethacin, and ibuprofen are substrates for MRP4 [76] and may interfere with fluorescent probe staining.

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans