ABCC4

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ABCC4

A gene on chromosome 13q32 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC4 is thought to play a role in cellular detoxification as an organic anion pump.
References in periodicals archive ?
Kroemer, "Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)," Drug Metabolism Reviews, vol.
Zelcer et al., "The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs," Proceedings of the National Academy of Sciences of the United States of America, vol.
Nakamura et al., "The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene," The Journal of Pharmacology and Experimental Therapeutics, vol.
In these cells, n-3 PUFAs reduce transcript levels of the BA synthesizing enzymes CYP7A1, CYP27, and CYP8B1 and of the apical BA importer NTCP, while increasing those of the BA exporters MRP2, MRP3, MRP4, and OST[beta] and of the metabolizing SULT2A1 enzyme (Figure 6).
Guibert et al., "Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice," The Journal of Clinical Investigation, vol.
Temperilli et al., "Enhanced platelet MRP4 expression and correlation with platelet function in patients under chronic aspirin treatment," Thrombosis and Haemostasis, vol.
Genes of interest were analyzed using TaqMan Master Mix and TaqMan Gene Expression Assays (Life Technologies): Sodium-dependent glucose cotransporter 1 (Sglt1), Rn00564718_m1; Sglt2, Rn00574917_m1; Oat1, Rn00568143_m1; Oat2, Rn00585513_m1; Oat3, Rn00580082_m1; Oct1, Rn00562250_m1; Oct2, Rn00580893_m1; Mrp2, Rn00563231_m1; Mrp4, Rn01465702_m1; P-glycoprotein (Mdr1b), Rn00561753_m1; Hnf1[alpha], Rn00562020_m1; Hnf1[beta], Rn00447453_m1; Hnf4[alpha], Rn00573309_m1.
Cells were treated with 25 p.M DAS, DADS and DAIS for 24 and 48 h and gene expression levels in colo 205 cells were determined for MRP1, MRP3, MRP4 and MRP6.
UDCA treatment of WT mice significantly increased nuclear Nrf2 expression and that of hepatic Mrp2, Mrp3, and Mrp4 [127].
For example, knocking out the gene encoding for MRP4 increases inflammatory pain threshold [45] and knocking out the gene encoding for MRP3 alters morphine pharmacokinetics [44].
MRP2, MRP4 and MRP5 are expressed in all cell variants, but the expression levels are differently distributed.
In particular, aspirin, indomethacin, and ibuprofen are substrates for MRP4 [76] and may interfere with fluorescent probe staining.