ABCC3

(redirected from MRP3)
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ABCC3

A gene on chromosome 17q22 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC3 is thought to play a role in the transport of biliary and intestinal excretion of organic anions.
References in periodicals archive ?
An additional protein in the ABC transporter family, MRP3, upregulates in cholestasis, protecting the hepatocytes from toxin-related damage and death.
Conjugated BS need to be actively transported into cholangiocytes via apical sodium-dependent bile acid transporter (ASBT, gene SLC10A2) and are exported into the peribiliary capillary plexus via the heterodimeric transporter OST[alpha]-OST[beta] and via MRP3 [28, 29].
The relatively high concentration of UGT, MRP2 and ABCG2 in the initial parts of the intestine, (duodenum and jejunum) might form a first line of defense against ingested xenobiotic compounds, while the presence of MRP3 in later portions of the intestine (ileum and colon) may ensure the absorption of specific nutrients and beneficial compounds.
Fifth factor which now have left by only public distribution system (MRP4) were added by another two compartments which had loading onto this factor as well; different pricing mechanism (MRP5) & controlled price at milling (MRP3).
Quantitative RT-PCR analyses revealed that EPA and/or DHA significantly downregulate the expression of genes controlling BA synthesis (CYP7A1 and CYP27) and uptake (NTCP), while genes involved in efflux (such as MRP2, MRP3, MRP4, and OST[beta]) and metabolism (SULT2A1) were upregulated (Figure 1(a)).
After incubation with MK 571, which inhibits MRP3 on the basolateral side, the AP to BL transport of rutin also decreased significantly (43.27 [+ or -] 2.18 versus 79.38 [+ or -] 2.79 nmol/L x mg x protein, P < 0.01, n = 7) and increased in the BL to AP direction (153.75 [+ or -] 5.66 versus 135.23 [+ or -] 5.65 nmol/L x mg x protein, P < 0.05, n = 7).
ABC transporter BBB BSCB Localization in (gene) brain capillary endothelium P-gp (ABCB1) Yes [24] Yes[35] Luminal [25] MRP1 (ABCC1) Yes [24, 25, 40] Yes[40] Luminal [25] Abluminal [24] MRP2 (ABCC2) Yes [24, 27] Yes[35] Luminal [25] MRP3 (ABCC3) Yes [24] ?
Morrow, "Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-delta(12,14)prostaglandin J2 in MCF7 breast cancer cells," Biochemistry, vol.
Heijn et al., "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, MDR3 P-glycoprotein with a panel of monoclonal antibodies," Cancer Research, vol.
Yokota et al., "MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas," Molecular Medicine Reports, vol.
Expression of drug resistance proteins Pg[micro]MRP1, MRP3, MRP5 and GST-pi in human glioma.
Isola, "Amplification and overexpression of the ABCC3 (MRP3) gene in primary breast cancer," Genes Chromosomes and Cancer, vol.