ABCC1

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ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.

References in periodicals archive ?

galloprovincialis mrp1 and mrp2 (Mg mrp1 and Mg mrp2), genes involved in the detoxification of okadaic acid in M.

VALIDATION OF REFERENCE GENES IN MUSSEL MYTILUS GALLOPROVINCIALIS TISSUES UNDER THE PRESENCE OF OKADAIC ACID

The work horses for detoxification are 1) MRP1, the transmembrane transporter serving most cells in the body for exporting toxins to circulation, 2) OATP, the basolateral membrane transporter which moves toxin conjugates from the blood into the hepatocytes or renal tubule epithelial cells, and 3) MRP2, the apical transporter that moves toxin conjugates (and some bile salts) into the bile canaliculus or renal proximal tubule lumen.

A Push-Catch System That Enables Effective Detoxification

Antibodies against multidrug-resistance-associated protein 1 (MRP1) (anti-MDR1 [U1C2]) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway

Souza e Silva et al., "MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer," International Journal of Cancer, vol.

Associations between the Epithelial-Mesenchymal Transition Phenotypes of Circulating Tumor Cells and the Clinicopathological Features of Patients with Colorectal Cancer

The [DELTA][DELTA]Ct method was used to calculate MDR-1, CRT, and MRP1 gene expression levels relative to control and the housekeeping gene [micro]-actin was used for normalization of MDR-1 expression.

Antimalarial Activity of Piperine

Klaassen, "Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats," The Journal of Pharmacology and Experimental Therapeutics, vol.

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

The three most well-studied transporters known for their efflux capabilities include P-glycoprotein (P-gp; ABCB1), multidrug resistance-associated protein 1 (MRP1; ABCC1), and breast cancer resistant protein (BCRP; ABCG2) [11, 21-24].

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations

Multidrug resistance associated protein 1 and 2 (MRP1 and2)###Wortelboer et al.

Recent advances in diagnostic and prognostic aspects of acute myeloid leukaemia

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

Geographic differences in persistent organic pollutant levels of yellowfin tuna

Among those, we selected, for the microarray and RNA-seq analyses, four PG transporters, ABCC1 (also known as MRP1), ABCC9 (also known as sulfonylurea receptor 2 [SUR2]), SLCO4C1 (also known as OATP4C1), and SLCO5A1 (also known as OATP5A1), because these have been shown to be differentially expressed in the uterine endometrium during early pregnancy [10,11].

Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs

The multidrug resistance protein-1 (MRP1) was suggested as a mediator of the effect of LTC4 on atherosclerosis.

Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

[sup.99m]Tc-MIBI is a substrate for PGP (P-glycoprotein, gene symbol ABCB1), MRP1 (multidrug resistance protein 1 (gene symbol ABCC1)), and MRP2 (multidrug resistance protein 2 (gene symbol ABCC2)) and can be used to image their expression in vivo [19].

Mathematical Simulation of Transport Kinetics of Tumor-Imaging Radiopharmaceutical [sup.99m]Tc-MIBI