This study is an important advance in our ability to combat the effects of high blood pressure," comments Claude Lenfant, director of the National Heart, Lung, and Blood Institute, which administered the 1973-1982 MRFIT
Researchers of MRFIT
, a randomized controlled trial of 12,866 men with a mean age of 46 years, followed the group prospectively for approximately 6.
Risk of End-Stage Renal Disease in Diabetes Mellitus: A Prospective Cohort Study of Men Screened for MRFIT
There clearly are some key candidate studies of interest: the MRFIT
follow-up, the Nurses Health Study, the Health Professional Studies, the Physicians Health Study, the Atherosclerosis Risk in Communities Study, the Coronary Artery Risk Development in Young Adults, or the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Lung Health Study, to name a few U.
Recently, data from the 11,688 men participating in the MRFIT
study have been published on the association of alcohol with CHD death (Suh, 1992).
This 10-year study, which followed 44,059 male health professionals ranging in age from 40 to 75, found that moderate consumption of alcohol reduced the risk of heart disease (not just risk of death from it, as MRFIT
showed) by 37%," the Johns Hopkins newsletter reports.
In the MRFIT
study, (9) high-risk men with asymptomatic ischemia were randomized to either usual care or a special intervention to reduce smoking, blood cholesterol, and diastolic blood pressure.
9) For cholesterol, both the MRFIT
research group and the Lipid Research Clinics Program report that a 1% decrease in serum cholesterol leads to a 2% reduction in coronary events.
Hymowitz N, Sexton M, Ockene J, Grandits G, for the MRFIT
Researchers reported the first MRFIT
findings in 1982.
Renal function change in hypertensive members of the multiple risk factor intervention trial racial and treatment effects the MRFIT
In the 40- to 44-year-old age group of MRFIT
(Multiple Risk Factor Intervention Trial), for example, the six-year heart attack rate in the 20 percent of men with the lowest cholesterol levels was 1.