MRC2

MRC2

A gene on chromosome 17q23.2 that encodes a C-type lectin domain protein which may play a role as a lectin receptor by internalising glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. Mannose receptor C-type 2 may play roles in plasminogen activation by controlling the extracellular level of PLAUR/PLAU; in cellular uptake and remodelling, and in degradation of extracellular collagen matrices; in cancer and chronic tissue-destructive diseases acting on collagen turnover; and may participate in extracellular matrix remodelling in concert with matrix metalloproteinases.
References in periodicals archive ?
Delivery will require to be made to the Police Scotland Logistics Department, MRC2, 91 Meiklewood Road, Glasgow, G51 4DU, or other locations as may be specified from time to time as and when required throughout the Contract period.
Multiple ICC markers, including galectin-3 (GAL-3), HBME-1, CK19, CXCR4, CD44, HMGA2, MRC2, SFN, and cyclins D1 and D3, have been investigated on cell block materials individually, and all have demonstrated some value in distinguishing benign from malignant lesions.
Metanalysis of 15,693 elderly patients with Systolic Hypertension Metanalysis of Systolic Hypertension Total Patients Average Age SHEP 4,736 72 SYST-EUR 4,695 70 SYST-CHINA 2,394 67 EWPHE 172 73 HEP 349 70 STOP 268 76 MRC1 428 62 MRC2 2,651 70 Table 4.