MRC study

MRC study

A clinical trial that evaluated the efficacy of drug therapy—beta-blockers (amiloride or atenolol)—and diuretics in older hypertensives

Conclusion
Hydrochlorothiazide and amiloride are better than atenolol in reducing hypertension-related events—strokes and coronary events—in older hypertensive patients.

Logistics
Randomised, single-blind, placebo-controlled multicenter trial.

Size 4396 patients.

Selection criteria Age 65–74, systolic BP ≥ 160–209, and diastolic BP < 115 mm Hg.
References in periodicals archive ?
Not surprisingly, the MRC study found that CNN's Anderson Cooper 360 and MSNBC's The Last Word With Lawrence O 'Donnell "were the most smitten with Avenatti, interviewing him the most of any program (20 times in the case of Cooper, 16 in the case of O'Donnell)."
This probably necessitated an increased interval between chemotherapy and surgery (median 93 days in the Intergroup trial and 63 days in OE02 trial) with fewer patients completing the chemotherapy (71% compared to 90% in OE02 trial) and may have also impacted on the percentage of patients undergoing resection in the trial; 80.3% of patients in chemotherapy arm in the Intergroup trial proceeded to surgery as opposed to 92% in the MRC study. The results from the OE02 trial led to neoadjuvant chemotherapy being widely accepted as standard of care.
To test the effect of folic acid supplementation, the MRC study group compared the outcomes of groups A and B with those in groups C and D.