MRC studyA clinical trial that evaluated the efficacy of drug therapy—beta-blockers (amiloride or atenolol)—and diuretics in older hypertensives
Hydrochlorothiazide and amiloride are better than atenolol in reducing hypertension-related events—strokes and coronary events—in older hypertensive patients.
Randomised, single-blind, placebo-controlled multicenter trial.
Size 4396 patients.
Selection criteria Age 65–74, systolic BP ≥ 160–209, and diastolic BP < 115 mm Hg.