MPZ

Also found in: Dictionary, Acronyms, Encyclopedia.

MPZ

A gene on chromosome 1q23.3 that encodes a major structural protein of peripheral myelin, which creates an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent
myelin lamellae.

Molecular pathology
MPZ mutations are linked to Charcot-Marie-Tooth disease type 1 and other polyneuropathies.

Mentioned in ?

References in periodicals archive ?

We applied this methodology in the setting studied by MPZ where c ~ 1/[100,1000] and N = 16 (the results are similar when using their assumption that N = 12).

Coupled with our previous nonexistence results from the median-price binding bids model and the overwhelmingly consistent evidence from MPZ, the conclusion is clear: the median-price auction is inefficient.

This also matches the experimental rules set forth in MPZ (2012) and allows for direct comparisons of our results to theirs.

Designed to fail: the Medicare auction for durable medical equipment

It is thicker at the base than the spine of the dorsal vertebra MPZ 2001/130c.

MPZ 2001/130 c shares the typical metriorhynchid morphology.

MPZ 2001/130 d shares some characters with the anterior caudal vertebrae of Cricosaurus (Herrera et al.

Postcranial elements of Maledictosuchus riclaensis (Thalattosuchia) from the Middle Jurassic of Spain

Although the majority of people will have a mutation in one of 4 genes [PMP22, MPZ, GJB1, or MFN2 (mitofusin 2)], it can be difficult determine the genetic cause if the test results for mutations in these genes are negative.

2] Human genes: PMP22, peripheral myelin protein 22; MPZ, myelin protein zero; GJB1, gap junction protein, beta 1, 32kDa; MFN2, mitofusin 2.

Sequence analysis of the 2 most frequently mutated genes, MPZ (myelin protein zero) and PMP22, identifies an additional 15% of CMT1 cases (1).

Increased serum creatine kinase

Mutation analysis in Chariot-Marie Tooth disease type 1: point mutations in the MPZ gene and the GJB1 gene cause comparable phenotypic heterogeneity.

TABLE 1 Clinical and genetic classification of hereditary motor and sensory neuropathy, with the linked locus and gene if known (Pestronk 2004) Pattern of Inhe- CMT-Type ritance Phenotype Locus Gene (s) Demyeli- Dominant CMT1A 17p11 PMP22 nating CMT1B; CMT1E 1q22 MPZ CMT1C 16p13 LITAF CMT1D 10q21 ERG2 CMT1F 8p21 NEFL HNPP l7p11 PMP22-deletion HMSN3 (Dejerine- PMP22/MPZ/ Sottas) EGR2/8q23 Thermosensitive ?

Genetics of hereditary motor and sensory neuropathy and the Costa Rican contribution