MPTP


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MPTP

Piperidine derivative that causes irreversible symptoms of parkinsonism in humans and monkeys. A by-product of illicitly manufactured meperidine that caused numerous cases of parkinsonism. Used as an experimental tool in research on parkinsonism.

MPTP

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia, muscular rigidity, resting tremor, defects of posture and gait Pharmacologic effects MPTP initially blocks the brain's responses to pain, then metabolizes to MPP+, causing an irreversible syndrome resembling Parkinson's disease. See BDNF, Designer drugs, Parkinson's disease.
References in periodicals archive ?
Las proteinas unidas a la mitocondria se encargan de regular su homeostasis por diversos mecanismos tales como insercion y formacion directa de un poro transmembranal, interaccion y regulacion del canal anionico dependiente de vohaje (VDAC) y del transportador de nucleotidos de adenosina (ANT), que conllevan a la aheracion del poro de permeabilidad transicional mitocondrial (mPTP).
A chemical known as MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine) causes a permanent form of parkinsonism that closely resembles Parkinson's disease.
Cell recordings at thalamic sites of active self-paced movements in the MPTP model have for technical reasons so far been limited but these should make further important contributions to the understanding of akinesia.
LPS: lipopolysaccharide; A[beta]: amyloid beta; MPTP: 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine; TBI: traumatic brain injury; SAH: subarachnoid hemorrhage; PI3k/AKT: phosphoinositide 3-kinase/protein kinase B; MAPKs: mitogen-activated protein kinases; NF-[kappa]B: nuclear factor-kappa B; JAK/STAT: Janus kinase/signal transducers and activators of transcription; NADPH oxidase: nicotinamide adenine dinucleotide phosphate oxidase; ROS: reactive oxygen species.
Neuroprotective effects of caffeine in MPTP model of Parkinson's disease: A(13)C NMR study.
Numerous studies show that opening of the MPTP is associated with common diseases of aging, and with markers of aging itself in human tissues.
Caption: Figure 8: Effect of HDAC inhibition on mitochondrial membrane potential and integrity of mitochondrial permeability transition pore (mPTP).
Mitochondrial permeability transition pores (MPTP) are nonspecific calcium-dependent channel composed of an inner and outer mitochondrial membrane component.
The pole test was performed one day before MPTP injection (day 0), 2 h after the fifth acupuncture stimulation (day 5), and 2 h after the last acupuncture stimulation (day 12).
The publication titled 'Gene Therapy for Parkinson's Disease: preclinical evaluation of an optimally configured TH: CH1 fusion for maximal Dopamine synthesis' reports safety and efficacy of AXO-LENTI-PD in the MPTP macaque model of Parkinson's disease.
[USA], June 23 (ANI): Contrary to earlier discovery that a chemical found in a synthetic opioid, MPTP, induced a form of Parkinson's disease, a new study has found that it is an enzyme in the body that can metabolise compounds formed in the brain from alkaloids causing a neurodegenerative condition in mice.
This model of PD was created by four intraperitoneal injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (4x20 mg/kg, at 12 h intervals).