The investigators propose that once MPTP
is converted to MPP.
Bakay and his colleagues administered MPTP
to rhesus monkeys.
STAT3 is now known to be present in cardiac mitochondria and be able to regulate ROS generation and MPTP
, which has been reported to cause oxidative stress in the brains of mice, induced TFEB upregulation in the animals, whereas the antioxidants NAC and SS-31 significantly reduced TFEB expression (Figure 3(d)).
In monkeys exposed to MPTP
5-14 years before death and free from MPTP
exposure for 3 years before death, biopsy data showed reactive microglia and extracellular melanin (McGeer et al.
Those experiments included transplants of dopamine-producing cells onto the brains of animals in which researchers had induced Parkinson-like symptoms with the chemical MPTP
, and transplants of adult human adrenal cells onto the brains of patients with Parkinson's disease.
attention deficit hyperactivity disorder, schizophrenia, PD), experimental studies have repeatedly demonstrated protective effects of estrogen in various experimental models, including protection against the DA toxicity associated with the experimental compound MPTP
as well as against methamphetamine-induced DA toxicity (Dluzen and McDermott 2002; Dluzen et al.
AEOL 11207 was tested for neuroprotection and oral bio-availability in the mouse MPTP
model of Parkinson's disease.
includes a comprehensive metro consists of 3 lines with a total length about 100 km and 70 stations .
Tipping points and endogenous determinants of nigrostriatal degeneration by MPTP
This raises concern because exposure to other mitochondrialinhibiting drugs - such as rotenone and MPTP
--is associated with increased risk for Parkinson's disease.
Neuroprotective effects of caffeine in MPTP
model of Parkinson's disease: A(13)C NMR study.