CCL23

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CCL23

A gene on chromosome 17q12 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL23 binds CCR1; it is chemotactic for resting T lymphocytes and monocytes, has some effect on neutrophils and no effect on activated T lymphocytes. CCL23 is a strong suppressor of colony formation by multipotential haematopoietic stem cells.
References in periodicals archive ?
MCP-2 (CCL8), MCP-3 (CCL7), MPIF-1 (CCL23) and 6 Ckine (CCL21) also belongs to the same family as HCC4 (CCL16) [34].
Yoshie, "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES," Journal of Interferon and Cytokine Research, vol.
Threshold value (pg/mL) Sensitivity IP-10 >1152.5 0.8571 MPIF-1 >189.62 1 CXCL7 >479.81 0.8571 6Ckine <5415.84 0.8571 I-TAC <34.21 0.8333 MCP-3 <24.49 1 MIF <1483.82 0.8571 95% CI for sensitivity Specificity IP-10 0.4868-0.9743 0.7857 MPIF-1 0.6456-1 0.5 CXCL7 0.4868-0.9743 0.7857 6Ckine 0.4868-0.9743 0.7857 I-TAC 0.4364-0.9699 0.9166 MCP-3 0.5101-1 0.833 MIF 0.4868-0.9743 0.9166 95% CI for specificity AUC 95% CI for AUC IP-10 0.5241-0.9242 0.8673 0.729-1 MPIF-1 0.2679-0.7320 0.7857 0.6075-1 CXCL7 0.5241-0.9242 0.8469 0.7034-1 6Ckine 0.5241-0.9242 0.7857 0.5666-1 I-TAC 0.6461-0.9851 0.875 0.7198-1 MCP-3 0.5519-0.9530 0.875 0.7222-1 MIF 0.6461-0.9851 0.8809 0.7385-1 Std.