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Standard inbred and congenic strain analyses suggested that lower Mpdz expression and/or certain variations in the amino acid sequence of the encoded MPDZ protein were associated with more severe ethanol withdrawal (Fehr et al.
Currently, little is known about how MPDZ function relates to alcohol dependence and withdrawal.
Through this association, MPDZ is involved in regulating the functions of the neurotransmitter glutamate, because after binding to SynGAP, MPDZ interacts (i.
MPDZ may affect withdrawal by altering the rate and/or fidelity of signal transduction mediated by one or more of the proteins with which it associates, particularly through its effects in a brain region(s) relevant to withdrawal.
Potential Roles of MPDZ and GIRK3 in Additional Responses to Ethanol
Ongoing analyses using MPDZ and GIRK3 genetic models can begin to address their potential roles in ethanol consumption, preference, and other related behaviors.
In addition, limited human association studies using only small populations have implicated MPDZ as potentially involved in excessive alcohol consumption and risk for alcoholism (Karpyak et al.
El doctor Victor Karpyak, del Departamento de Psiquiatria y Psicologia de Clinica Mayo, exploro la secuencia del gen MPDZ en los humanos v su vinculacion al riesgo de presentar dependencia alcoholica y convulsiones, abstinencia del habito.
El gen MPDZ maneja los mecanismos cerebrales encargados de la estructura sinaptica y plasticidad, y esta involucrado en el proceso de aprendizaje y en la memoria, asi com vulsiones y epilepsia; por ello, es un buen candidato para el estudio en humanos concentrado en descubrir vaticinadores geneticos para la abstinencia alcoholica.
cion del gen MPDZ en el alcoholismo y sus complicaciones.
The behavioral significance of the seizure phenotype, however, is less clear cut because human studies thus far have failed to show a specific association between MPDZ and withdrawal (Karpyak et al.
Studies of this gene's pattern of expression in the brain and of the functions of the MPDZ protein continue, as do studies to identify the receptor molecules with which MPDZ interacts (e.
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