KAT6A

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KAT6A

A gene on chromosome 8p11 that encodes a histone acetyltransferase which acetylates lysine residues in histone H3 and histone H4. KAT6A is part of the MOZ/MORF complex which has histone H3 acetyltransferase activity. It may act as a transcriptional coactivator for RUNX1 and RUNX2.
 
Molecular pathology
Defects in KAT6A have been linked to acute myeloid leukaemias and myelodysplastic syndrome by various translocations resulting in oncogenes and fusion proteins.
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