SAMHD1

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SAMHD1

A gene on chromosome 20pter-q12 that encodes a putative nuclease involved in the innate immune response, which acts by downregulating cell-intrinsic antiviral response. It may play a role in mediating pro-inflammatory responses to TNF-alpha signalling. It is expressed in the heart, skeletal muscle, spleen, liver and elsewhere, but not in the brain or thymus.

Molecular pathology
Defects in SAMHD1 cause Aicardi-Goutieres syndrome type 5 and chilblain lupus type 2.
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References in periodicals archive ?
sieberii, (CTC11) from C colocynthis and (MOP5) from M.
Among the screened isolates, three selected endophytes (ART 7, CTC11 and MOP5) with greater than 12 mm zone of inhibition were taken for further studies.
The MIC of ethanolic extracts of these three selected endophytes (ART 7, CTC11 and MOP5) is summarized in Table-2.
The Macau banking sector ended the 2012 financial year with customer deposits valued at over MOP550bn, profits of over MOP5.7bn and total assets exceeding MOP790bn.
COP15 was MOP5, and so it is sometimes referred to as COP15/MOP5 or CMP15, ie the Conference of the Parties serving as the Meeting of the Parties.