MODY2

MODY2

Abbreviation for:
maturity onset diabetes of the young type 2 (see there)
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References in periodicals archive ?
Tumini et al., "A new de novo mutation in the GCK gene causing MODY2," Diabetes Research and Clinical Practice, vol.
MODY3 and MODY2 are the most common forms and MODY2 does not predispose to the complication of microvascular diabetic complications [77,78].
Rodriguez et al., "Clinical differences between patients with MODY-3, MODY2 and type 2 diabetes mellitus with I27L polymorphism in the HNF1[alpha] gene," Endocrinologia y Nutricion, vol.
Several subtypes of MODY have been described in women with GDM, including MODY2 (mutation in glucokinase gene), MODY3 (mutation in hepatocyte nuclear factor 1a), and MODY4 (mutation in insulin promoter factor 1) [22].
Velho, "Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2)," Diabetes Care, vol.
We will focus on the management of MODY2 (GCK mutation) and 3 (HNF1-a mutation), which are the most common subtypes, accounting for more than 70% of cases.
Genetic defects in six genes are known to cause MODY: the hepatocyte nuclear factor-4[alpha]: HNF-4[alpha]/(MODY1); glucokinase: GCK/(MODY2); the hepatocyte nuclear factor-1[alpha]: HNF-1[alpha]/(MODY3); insulin promoter factor-1: IPFl/ (MODY4); hepatocyte nuclear factor-1[beta]: HNF-1[beta]/(MODY5); and transcriptional factor, neurogenic differentiation1: Neuro-D1/(MODY 6) (3-5).
Mutations in the glucokinase gene lead to an impaired sensing of blood glucose by the pancreatic [beta] cell, causing an autosomal dominant form of type 2 diabetes, maturity-onset diabetes of the young type 2 (MODY2).
Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2).
Moreover, the promoter and the complete coding region for isoform 1 of GCK gene was sequenced in 13 pregnant women with suspect MODY2. In detail, fragments containing the promoter and ten exons were amplified by PCR using specific primers designed based on the reference gene sequence.
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY2 families.